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EJNMMI Research

Table 2 Histological parameters, evaluated using H&E and SR staining

From: Quantitative evaluation of hepatic integrin αvβ3 expression by positron emission tomography imaging using 18F-FPP-RGD2 in rats with non-alcoholic steatohepatitis

Parameters

Group

3–4 weeks

9–10 weeks

Normal diet

CDHFD

Normal diet

CDHFD

Steatosis score

0.0 ± 0.0

3.0 ± 0.0 **

0.0 ± 0.0

3.0 ± 0.0 **

Inflammation score

0.0 ± 0.0

1.4 ± 0.55 **

0.20 ± 0.45

2.6 ± 0.55 **, ††

Ballooning score

0.0 ± 0.0

0.20 ± 0.45

0.0 ± 0.0

1.0 ± 0.0 **, †

NAFLD activity score

0.0 ± 0.0

4.6 ± 0.89 **

0.20 ± 0.45

6.6 ± 0.55 **, ††

Fibrosis area (%)

1.0 ± 0.0

1.4 ± 0.5

1.0 ± 0.0

19.8 ± 10 *, †

  1. Values are expressed as means ± SDs (n = 5). *P < 0.05, **P < 0.01, compared with the respective normal diet-fed groups; †P < 0.05; ††P < 0.01, compared with the 3–4-week CDHFD-fed group
  2. H&E haematoxylin and eosin, SR Sirius red, CDHFD choline-deficient, low-methionine high-fat diet, NAFLD non-alcoholic fatty liver disease
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