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Table 2 Histological parameters, evaluated using H&E and SR staining

From: Quantitative evaluation of hepatic integrin αvβ3 expression by positron emission tomography imaging using 18F-FPP-RGD2 in rats with non-alcoholic steatohepatitis

Parameters Group
3–4 weeks 9–10 weeks
Normal diet CDHFD Normal diet CDHFD
Steatosis score 0.0 ± 0.0 3.0 ± 0.0 ** 0.0 ± 0.0 3.0 ± 0.0 **
Inflammation score 0.0 ± 0.0 1.4 ± 0.55 ** 0.20 ± 0.45 2.6 ± 0.55 **, ††
Ballooning score 0.0 ± 0.0 0.20 ± 0.45 0.0 ± 0.0 1.0 ± 0.0 **, †
NAFLD activity score 0.0 ± 0.0 4.6 ± 0.89 ** 0.20 ± 0.45 6.6 ± 0.55 **, ††
Fibrosis area (%) 1.0 ± 0.0 1.4 ± 0.5 1.0 ± 0.0 19.8 ± 10 *, †
  1. Values are expressed as means ± SDs (n = 5). *P < 0.05, **P < 0.01, compared with the respective normal diet-fed groups; P < 0.05; ††P < 0.01, compared with the 3–4-week CDHFD-fed group
  2. H&E haematoxylin and eosin, SR Sirius red, CDHFD choline-deficient, low-methionine high-fat diet, NAFLD non-alcoholic fatty liver disease