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Table 1 Body and liver masses, liver/body mass ratio and biochemical parameters

From: Quantitative evaluation of hepatic integrin αvβ3 expression by positron emission tomography imaging using 18F-FPP-RGD2 in rats with non-alcoholic steatohepatitis

Parameters

Group

3–4 weeks

9–10 weeks

Normal diet

CDHFD

Normal diet

CDHFD

Body weight (g)

299.1 ± 20.5

206.2 ± 15.7**

433.3 ± 16.2

246.0 ± 11.9**

Liver weight (g)

9.9 ± 0.8

13.9 ± 2.1**

12.1 ± 12

18.8 ± 2.9**

Liver/body weight ratio

0.033 ± 0.001

0.067 ± 0.007**

0.028 ± 0.002

0.076 ± 0.008**

AST (IU/L)

74.9 ± 12.6

564 ± 438

62.7 ± 16.6

566 ± 229**

ALT (IU/L)

45.1 ± 13.1

760 ± 528*

38.6 ± 15.9

229 ± 94.6*

TC (mg/dL)

56.4 ± 4.4

31.4 ± 3.1

51.7 ± 10.4

66.6 ± 23.7

TG (mg/dL)

96.2 ± 33.4

4.6 ± 3.2**

184 ± 131

8.1 ± 4.6*

GLU (mg/dL)

192 ± 20.1

143 ± 13.8**

201 ± 18.1

127 ± 16.6**

TBA (mg/dL)

7.6 ± 4.6

117 ± 91.3

13.2 ± 12.2

138 ± 75.1*

ALB (g/dL)

2.2 ± 0.1

2.3 ± 0.1

2.3 ± 0.1

2.1 ± 0.2*

ALP (IU/L)

518 ± 75.7

1109 ± 427*

316 ± 69.7

1757 ± 818*

T-BIL (mg/dL)

0.11 ± 0.02

0.44 ± 0.24*

0.09 ± 0.02

0.66 ± 0.41*

  1. Values are expressed as means ± SDs (n = 5). *P < 0.05, **P < 0.01, compared with the respective normal diet-fed group
  2. CDHFD choline-deficient, low-methionine high-fat diet, AST aspartate aminotransferase, ALT alanine aminotransferase, TC total cholesterol, TG triglyceride, GLU glucose, TBA total bile acids, ALB albumin, ALP alkaline phosphatase, T-BIL total bilirubin