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Table 3 Biodistribution data of control, diabetic and obese mice at room temperature, under acute cold and cold acclimation 30 min after injection of [18F]BDP-TG-chylomicron-like particles, expressed as %IA/g

From: Brown adipose tissue uptake of triglyceride-rich lipoprotein-derived fatty acids in diabetic or obese mice under different temperature conditions

 

Control

Diabetic

Obese

21 °C (%)

Acute cold (%)

Cold accl (%)

21 °C (%)

Acute cold (%)

Cold accl (%)

21 °C (%)

Acute cold (%)

Cold accl (%)

Blood

3.9 ± 0.7

4.5 ± 2.6

4.3 ± 1.4

4.4 ± 0.3

4.9 ± 0.6

4.5 ± 0.3

4.9 ± 0.7

4.6 ± 2.9

4.1 ± 2.3

Heart

16.9 ± 4.1

19.9 ± 9.8

17.2 ± 3.3

23.7 ± 1.9

23.8 ± 6.6

25.5 ± 7.2

12.1 ± 1.7

11.4 ± 5.8

12.1 ± 5.7

Lung

18.0 ± 16.8

16.0 ± 5.0

9.7 ± 1.7

10.7 ± 3.9

10.2 ± 0.7

14.7 ± 12.1

5.2 ± 0.3

16.0 ± 4.9

17.0 ± 13.0

Liver

21.5 ± 2.0

23.7 ± 3.0

24.9 ± 3.6

37.4 ± 3.3

33.4 ± 2.1

38.4 ± 0.5

16.7 ± 1.2

21.5 ± 3.3

18.9 ± 3.9

Spleen

30.8 ± 16.9

32.3 ± 14.8

39.3 ± 21.3

38.7 ± 6.9

50.3 ± 9.7

33.4 ± 1.2

15.5 ± 1.9

24.8 ± 10.5

18.9 ± 3.7

Stomach

2.3 ± 1.3

3.2 ± 1.1

1.6 ± 0.3

2.7 ± 0.2

2.9 ± 1.5

1.9 ± 0.1

2.4 ± 0.7

2.0 ± 0.5

1.7 ± 1.1

Pancreas

2.2 ± 1.0

5.1 ± 3.9

2.3 ± 1.4

3.2 ± 0.8

2.9 ± 0.5

2.8 ± 0.7

1.9 ± 0.3

4.3 ± 3.3

3.0 ± 3.8

Kidneys

5.6 ± 0.5

6.3 ± 3.1

5.7 ± 1.0

9.0 ± 1.5

9.0 ± 1.5

9.9 ± 2.1

5.3 ± 0.5

6.2 ± 1.6

5.6 ± 2.0

Intestines

2.3 ± 0.4

2.2 ± 0.4

2.3 ± 0.5

3.8 ± 0.6

2.8 ± 0.3

2.7 ± 0.7

3.3 ± 0.6

2.7 ± 0.5

2.8 ± 1.0

Muscle

2.4 ± 1.1

2.0 ± 1.6

1.4 ± 0.6

1.6 ± 0.3

1.1 ± 0.6

1.2 ± 0.6

1.5 ± 0.2

1.6 ± 0.6

1.3 ± 0.3

Bone

7.1 ± 2.6

7.1 ± 3.6

5.8 ± 3.2

4.3 ± 0.9

4.4 ± 0.8

5.3 ± 1.3

9.2 ± 2.5

6.5 ± 4.8

5.2 ± 1.9

WAT

2.7 ± 1.4

3.7 ± 2.9

2.4 ± 0.9

1.9 ± 0.4

1.8 ± 1.2

1.4 ± 0.1

1.5 ± 0.9

0.8 ± 0.6

0.7 ± 0.2

Skin

1.6 ± 0.6

1.5 ± 0.7

1.5 ± 0.4

1.3 ± 0.2

1.9 ± 0.9

1.2 ± 0.2

1.1 ± 0.1

1.5 ± 0.5

1.1 ± 0.2

BAT

9.6 ± 1.7

15.1 ± 4.7

7.6 ± 1.9

8.0 ± 1.3

8.2 ± 1.4

9.2 ± 1.8

5.1 ± 0.6

8.0 ± 1.8

6.9 ± 1.4 ‬

Aorta

9.7 ± 4.5

13.1 ± 3.1

10.1 ± 6.4

4.9 ± 0.9

6.8 ± 3.3

6.0 ± 1.5

3.0 ± 2.7

6.5 ± 2.0

5.1 ± 1.0

Brain

0.6 ± 0.7

0.4 ± 0.3

0.3 ± 0.1

0.2 ± 0.0

0.2 ± 0.0

0.2 ± 0.0

0.2 ± 0.0

0.2 ± 0.1

0.4 ± 0.4

Remainder

8.0 ± 0.4

7.3 ± 0.5

7.6 ± 0.8

7.2 ± 1.0

6.6 ± 0.2

6.5 ± 0.3

6.8 ± 0.5

7.0 ± 0.9

6.9 ± 1.0