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Table 2 Fit parameters of four-compartment models for [11C]mHED myocardial uptake in mice (mean of 3 independent scans, SD in parentheses)

From: [11C]mHED PET follows a two-tissue compartment model in mouse myocardium with norepinephrine transporter (NET)-dependent uptake, while [18F]LMI1195 uptake is NET-independent

 

TCM1

TCM2p

TCM2s

TCM2v

K1 (ml/min/cm3)

0.868 (0.113)

0.499 (0.153)

0.947 (0.146)

0.947 (0.146)

k2 (1/min)

0.029 (0.01)

0.0125 (0.0034)

0.0672 (0.0062)

0.0672 (0.0062)

k3 (1/min),

0.0541 (0.0263)

0.0669 (0.0344)

K3 (ml/min/cm3)

0.448 (0.114)

k4 (1/min)

0.134 (0.040)

0.0254 (0.0117)

0.0125 (0.0034)

vb (–)

0.497 (0.006)

0.464 (0.035)

0.464 (0.035)

0.464 (0.035)