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EJNMMI Research
Fig. 7 | EJNMMI Research

Fig. 7

From: [11C]mHED PET follows a two-tissue compartment model in mouse myocardium with norepinephrine transporter (NET)-dependent uptake, while [18F]LMI1195 uptake is NET-independent

Fig. 7

a Dose dependency and desipramine sensitivity of K1 in the TCM2s and TCM2v. Dose of combined [11C]mHED and metaraminol up to 61.6 nmol/kg. The highest dose in the plot (66 µmol/kg) corresponds to 20 mg desipramine HCl to fully saturate NET. b K1 of TCM1 correlated with K1 of the more complex TCM2s or TCM2v. Slope, intercept, r2, and p as indicated. c K1 of the TCM2s and TCM2v correlated with SUV1–31 min. SUV1–31 min may serve as a surrogate parameter for NET transport activity. r2 and p for the data including scans with desipramine ("all data", regression lines) and without desipramine scans ("w/o desi"), as indicated. Note that for the estimation of K1, 11 of the 14 scans were analysed with a surrogate input function. Red symbols, scan with an input function

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