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EJNMMI Research
Fig. 4 | EJNMMI Research

Fig. 4

From: [11C]mHED PET follows a two-tissue compartment model in mouse myocardium with norepinephrine transporter (NET)-dependent uptake, while [18F]LMI1195 uptake is NET-independent

Fig. 4

Dose dependency of [11C]mHED uptake in the mouse myocardium. a TACs (SUV) of myocardium at the indicated dose of combined [11C]mHED and metaraminol. Desipramine, 66′000 nmol/kg, corresponds to 20 mg/kg desipramine HCl. Broken vertical lines indicate 1 and 31 min, respectively, the time window for SUV1–31 min averaging. TACs with shorter time intervals are from the scans for kinetic modelling. b SUV1–31 min was plotted against the dose on logarithmic scale (base 10). Solid line, fit according to Eq. 3 with fit D50 = 88.3 nmol/kg. Broken lines, 95% confidence intervals. Broken vertical line indicates 1/10 D50

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