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Fig. 7 | EJNMMI Research

Fig. 7

From: [68Ga]ABY-028: an albumin-binding domain (ABD) protein-based imaging tracer for positron emission tomography (PET) studies of altered vascular permeability and predictions of albumin-drug conjugate transport

Fig. 7

Comparison of changes in metabolism and permeability with tumor progression in a NIH-Foxn1mu rat bearing two FaDu xenografts. a Maximum intensity projection PET image of [18F]FDG uptake on day 3 showing the localization of the xenograft tumors (T) to the left and right; H, heart. b The time line for imaging experiments. c, d Coronal PET images for the left and right tumors, respectively: the top rows are of [18F]FDG uptake on day 0 and day 3, dual time imaging on each day, and the bottom rows are of [68Ga]ABY-028 uptake on day 1 and day 4, dual time imaging on each day, but at different times for the two tracers (shown immediately above each image). The same magnification was used in the images. The bar shows the color scale used. Note: to facilitate visual comparisons the SUVmean, ranges in the color bar are the same for all the [18F]FDG images (0–6) and for all the [68Ga]ABY-028 (0–1.6), but are different for the two tracers due to their differing levels of total uptake

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