Fig. 6
Comparison of metabolism and permeability in a MMTV-PyMT mouse with multiple mammary tumors, two of these depicted here by the brackets and as T1 and T4, arrowheads showing other tumors. a, d Coronal PET images of the radioactivity uptake after i.v. injection of [18F]FDG and [68Ga]ABY-028, respectively. The different scales of the SUVs in the images are shown in the color bars to the right of each image. b, c, e, f Profiles of radioactivity concentrations along a ruler placed at one position (placements shown in the gray inserts above each graph) in T1 and T4. Only one graph for [18F]FDG uptake is shown in b (T1) and c (T2) since the peaks and profiles did not change appreciably after the early uptake phase. With [68Ga]ABY-028 in e and f the 0–1 min profile indicated the vascular radioactivity while the subsequent profiles visualized the changes in the degree and local heterogeneity of the leakage of the albumin-bound radioactivity into parts of the tumors over time