Phase I metabolism | Phase II metabolism | ||||
---|---|---|---|---|---|
Process | Substrate | Product | Process | Substrate | Product |
Oxidation | Aromatic compounds Aliphatic compounds Aromatic ethers Aromatic amine Tertiary Amine | Hydroxylated compound Alcohol, aldehyde, ketones, acids Phenols and Aliphatic aldehydes Hydroxyamino compound N-Oxide | Glucuronidation | Alcohol or phenol derivatives of the radiotracers and glucuronic acid | Conjugated Ester |
Reduction | Aldehydes, ketones Carbon–carbon double bond Nitro group | Alcohols Corresponding saturated compounds Corresponding amine | Sulphonation | Alcohol and phenol derivatives of the radiotracers and its metabolites | Conjugated product |
Hydrolysis | Ester, amide | Acid | Acetylation | Aliphatic or aromatic amine | Amides |