Skip to main content

Table 2 Overview of trials reporting on the correlation between a preoperative nuclear imaging examination and postoperative mortality

From: Nuclear imaging methods for the prediction of postoperative morbidity and mortality in patients undergoing localized, liver-directed treatments: a systematic review

Author Mortality defined Mortality event rate Preset cut off studied Post hoc cut-off value established Only descriptive analysis Mortality vs no mortality comparison Key diagnostic characteristics reported Cut-off value predictive in univariate regression analysis Cut-off value predictive in multivariate regression analysis
Das et al. [23] Yes 4% No Yes Yes NR NR NR NR
Dinant et al. [24] No 11% No Yes No Yes Yes Yes No
Cieslak et al. [16] Yes 7% Yes No Yes NR NR NR NR
Chapelle et al. [19] Yes 6% No Yes1 Yes NR NR NR NR
Chapelle et al. [20] Yes 0%2 Yes1 No Yes NR NR NR NR
Chiba et al. [18] No3 2% Yes1 No Yes NR NR NR NR
Franken et al. [25] Yes 13%4 Yes No Yes5 NR NR NR NR
Fujioka et al. ≠ [26] No 7% No Yes Yes NR NR NR NR
Guiu et al. [27] Yes 0% Yes No Yes NR NR NR NR
Hayashi et al. [28] Yes 6% Yes No No NR NR Yes NR
Hino et al. [29] No 6% No Yes6 Yes NR NR NR NR
Kaibori et al. [34] No 2% No Yes1 Yes NR NR NR NR
Kim et al. ≠ [39] No 10% No Yes No Yes NR NR Yes
Kwon et al. [42] No 2% No Yes Yes NR NR NR NR
Kwon et al. [43] No 2% No Yes Yes NR NR NR NR
Kwon et al. [44] No 3% No Yes Yes NR NR NR NR
Kwon et al. [45] No 1% No Yes Yes NR NR NR NR
Kwon et al. ≠ [46] No 1% No Yes6 Yes NR NR NR NR
Namieno et al. [53] No 0% Yes No Yes NR NR NR NR
Nishikawa et al. [60] Yes 42% No Yes No Yes7 NR Yes Yes
Nishiyama et al. [61] No 10% No Yes No NR Yes NR NR
Okabayashi et al. [63] Yes 1% Yes No Yes NR NR NR NR
Olthof et al. [65] Yes 18% Yes8 Yes8 No NR Yes8 NR NR
Otsuki et al. [66] No 27% No Yes No Yes NR NR NR
Rassam et al. [67] Yes 11% Yes No No Yes NR NR NR
Satoh et al. ≠ [68] No 4% No Yes6 No NR Yes6 NR NR
Serenari et al. [69] Yes 5% No Yes9 Yes NR NR NR NR
Sumiyoshi et al. [75] Yes 0% Yes No Yes NR NR NR NR
Takeuchi et al. ≠ [76] No 8% No No No Yes6 NR NR NR
Tanabe et al. [77] No 52% No Yes No Yes NR NR NR
Tanaka et al. [79] No 2%10 Yes No Yes NR NR NR NR
Truant et al. [82] No 20% No No Yes NR NR NR NR
Truant et al. [83] No 14%11 No No Yes NR NR NR NR
Yamao et al. [87] Yes 25%12 No No No NR NR No NR
Yano et al. [89] Yes 18%13 No Yes No Yes7 NR NR No
Yumoto et al. [92] No 12% No Yes Yes NR NR NR NR
Yumoto et al. [93] No 3% No Yes Yes NR NR NR NR
  1. Papers with mortality as part of a composite endpoint are marked with a “≠”; in those cases, the data are reported for overall complications in which mortality is included unless otherwise stated
  2. NR not reported
  3. 1The cut-off value established for the prediction of postoperative LF is also used for the outcome mortality
  4. 2No patients in the interventional group died postoperatively, but in the 88 patients in the prior study by Chapelle et al. the mortality rate was 6%, also reported in the table above
  5. 3Two patients died due to LF during the hospital stay. The NMT uptake values are reported for these two patients
  6. 4In the overall population including the cohort from 2000 to 2015 and the cohort from 2016 to 2019
  7. 5Comparison of outcomes in the cohort from 2000 to 2015 to those in the cohort from 2016 to 2019 applying different cut-off values for the function of the FLR
  8. 6Cut-off value, diagnostic characteristics, or mortality vs. no mortality for overall complications or poor outcome, but separate uptake values reported for patients who died postoperatively
  9. 7They perform a log-rank test to compare survival rates in patients with liver uptake function above and below a certain level
  10. 8Cut-off value for postoperative LF
  11. 9AUC value only investigated for patients developing LF-related mortality (16%)
  12. 10Only in 98 patients who underwent hemi-hepatectomy did the authors evaluate mortality and LF. Therefore, the mortality event rate was 2/98 (2%)
  13. 11Postoperative clinical outcomes were only reported in the seven patients who underwent ALPPS. One of the seven patients died due to LF postoperatively
  14. 125-year overall mortality rate based on the reported 5-year overall survival rates of 55.2% in one group (n = 24) and 77.3% in another group (n = 259)
  15. 135-year overall mortality rate based on the reported 5-year overall survival rate of 82%. The 3-year tumor-free survival rate was 41%