Nuclear imaging methods for the prediction of postoperative morbidity and mortality in patients undergoing localized, liver-directed treatments: a systematic review

Espersen, Caroline; Borgwardt, Lise; Larsen, Peter Nørgaard; Andersen, Trine Borup; Stenholt, Louise; Petersen, Lars Jelstrup

doi:10.1186/s13550-020-00687-1

EJNMMI Research

Table 2 Overview of trials reporting on the correlation between a preoperative nuclear imaging examination and postoperative mortality

From: Nuclear imaging methods for the prediction of postoperative morbidity and mortality in patients undergoing localized, liver-directed treatments: a systematic review

Author	Mortality defined	Mortality event rate	Preset cut off studied	Post hoc cut-off value established	Only descriptive analysis	Mortality vs no mortality comparison	Key diagnostic characteristics reported	Cut-off value predictive in univariate regression analysis	Cut-off value predictive in multivariate regression analysis
Das et al. [23]	Yes	4%	No	Yes	Yes	NR	NR	NR	NR
Dinant et al. [24]	No	11%	No	Yes	No	Yes	Yes	Yes	No
Cieslak et al. [16]	Yes	7%	Yes	No	Yes	NR	NR	NR	NR
Chapelle et al. [19]	Yes	6%	No	Yes¹	Yes	NR	NR	NR	NR
Chapelle et al. [20]	Yes	0%²	Yes¹	No	Yes	NR	NR	NR	NR
Chiba et al. [18]	No³	2%	Yes¹	No	Yes	NR	NR	NR	NR
Franken et al. [25]	Yes	13%⁴	Yes	No	Yes⁵	NR	NR	NR	NR
Fujioka et al. ≠ [26]	No	7%	No	Yes	Yes	NR	NR	NR	NR
Guiu et al. [27]	Yes	0%	Yes	No	Yes	NR	NR	NR	NR
Hayashi et al. [28]	Yes	6%	Yes	No	No	NR	NR	Yes	NR
Hino et al. [29]	No	6%	No	Yes⁶	Yes	NR	NR	NR	NR
Kaibori et al. [34]	No	2%	No	Yes¹	Yes	NR	NR	NR	NR
Kim et al. ≠ [39]	No	10%	No	Yes	No	Yes	NR	NR	Yes
Kwon et al. [42]	No	2%	No	Yes	Yes	NR	NR	NR	NR
Kwon et al. [43]	No	2%	No	Yes	Yes	NR	NR	NR	NR
Kwon et al. [44]	No	3%	No	Yes	Yes	NR	NR	NR	NR
Kwon et al. [45]	No	1%	No	Yes	Yes	NR	NR	NR	NR
Kwon et al. ≠ [46]	No	1%	No	Yes⁶	Yes	NR	NR	NR	NR
Namieno et al. [53]	No	0%	Yes	No	Yes	NR	NR	NR	NR
Nishikawa et al. [60]	Yes	42%	No	Yes	No	Yes⁷	NR	Yes	Yes
Nishiyama et al. [61]	No	10%	No	Yes	No	NR	Yes	NR	NR
Okabayashi et al. [63]	Yes	1%	Yes	No	Yes	NR	NR	NR	NR
Olthof et al. [65]	Yes	18%	Yes⁸	Yes⁸	No	NR	Yes⁸	NR	NR
Otsuki et al. [66]	No	27%	No	Yes	No	Yes	NR	NR	NR
Rassam et al. [67]	Yes	11%	Yes	No	No	Yes	NR	NR	NR
Satoh et al. ≠ [68]	No	4%	No	Yes⁶	No	NR	Yes⁶	NR	NR
Serenari et al. [69]	Yes	5%	No	Yes⁹	Yes	NR	NR	NR	NR
Sumiyoshi et al. [75]	Yes	0%	Yes	No	Yes	NR	NR	NR	NR
Takeuchi et al. ≠ [76]	No	8%	No	No	No	Yes⁶	NR	NR	NR
Tanabe et al. [77]	No	52%	No	Yes	No	Yes	NR	NR	NR
Tanaka et al. [79]	No	2%¹⁰	Yes	No	Yes	NR	NR	NR	NR
Truant et al. [82]	No	20%	No	No	Yes	NR	NR	NR	NR
Truant et al. [83]	No	14%¹¹	No	No	Yes	NR	NR	NR	NR
Yamao et al. [87]	Yes	25%¹²	No	No	No	NR	NR	No	NR
Yano et al. [89]	Yes	18%¹³	No	Yes	No	Yes⁷	NR	NR	No
Yumoto et al. [92]	No	12%	No	Yes	Yes	NR	NR	NR	NR
Yumoto et al. [93]	No	3%	No	Yes	Yes	NR	NR	NR	NR

Papers with mortality as part of a composite endpoint are marked with a “≠”; in those cases, the data are reported for overall complications in which mortality is included unless otherwise stated
NR not reported
¹The cut-off value established for the prediction of postoperative LF is also used for the outcome mortality
²No patients in the interventional group died postoperatively, but in the 88 patients in the prior study by Chapelle et al. the mortality rate was 6%, also reported in the table above
³Two patients died due to LF during the hospital stay. The NMT uptake values are reported for these two patients
⁴In the overall population including the cohort from 2000 to 2015 and the cohort from 2016 to 2019
⁵Comparison of outcomes in the cohort from 2000 to 2015 to those in the cohort from 2016 to 2019 applying different cut-off values for the function of the FLR
⁶Cut-off value, diagnostic characteristics, or mortality vs. no mortality for overall complications or poor outcome, but separate uptake values reported for patients who died postoperatively
⁷They perform a log-rank test to compare survival rates in patients with liver uptake function above and below a certain level
⁸Cut-off value for postoperative LF
⁹AUC value only investigated for patients developing LF-related mortality (16%)
¹⁰Only in 98 patients who underwent hemi-hepatectomy did the authors evaluate mortality and LF. Therefore, the mortality event rate was 2/98 (2%)
¹¹Postoperative clinical outcomes were only reported in the seven patients who underwent ALPPS. One of the seven patients died due to LF postoperatively
¹²5-year overall mortality rate based on the reported 5-year overall survival rates of 55.2% in one group (n = 24) and 77.3% in another group (n = 259)
¹³5-year overall mortality rate based on the reported 5-year overall survival rate of 82%. The 3-year tumor-free survival rate was 41%

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