Nuclear imaging methods for the prediction of postoperative morbidity and mortality in patients undergoing localized, liver-directed treatments: a systematic review

Espersen, Caroline; Borgwardt, Lise; Larsen, Peter Nørgaard; Andersen, Trine Borup; Stenholt, Louise; Petersen, Lars Jelstrup

doi:10.1186/s13550-020-00687-1

EJNMMI Research

Table 1 Study demographics of the included papers

From: Nuclear imaging methods for the prediction of postoperative morbidity and mortality in patients undergoing localized, liver-directed treatments: a systematic review

Author	Year	Country	Prospective study	Consecutive recruitment	Tracer	Patients (n)	Postoperative outcome (correlated to NMT)				Major/minor surgery or both
Author	Year	Country	Prospective study	Consecutive recruitment	Tracer	Patients (n)	Mortality	Liver failure	Morbidity	Liver function tests
Bennink et al. [14]	2004	The Netherlands	Yes	Yes	[^99mTc]Tc-Meb	15	No	No	No	Yes	Both
Beppu et al. [15]	2018	Japan	Yes	No	[^99mTc]Tc-GSA	40	No	No	No	Yes	Major
Cieslak et al. [16]	2016	The Netherlands	No	Yes	[^99mTc]Tc-Meb	163	Yes	Yes	Yes	No	Major
Cieslak et al. [17]	2017	The Netherlands	No	Yes	[^99mTc]Tc-Meb	46	No	Yes	No	No	Major
Chiba et al. [18]	2017	Japan	No	Yes	[^99mTc]Tc-GSA	123	Yes	Yes	No	No	Both
Chapelle et al. [19]	2016	Belgium	Yes	Yes	[^99mTc]Tc-Meb	88	Yes	Yes	No	No	Both
Chapelle et al. [20]	2017	Belgium	Yes	Yes	[^99mTc]Tc-Meb	188¹	Yes	Yes	No	Yes	Both
Chapelle et al. [21]	2017	Belgium	No	Yes	[^99mTc]Tc-Meb	140	No	Yes	No	Yes	Both
Cho et al. [22]	2017	Korea	No	Yes	[¹⁸F]FDG	149	No	Yes	No	No	Both
Das et al. [23]	2001	Japan	No	Yes	[^99mTc]Tc-GSA	100	Yes	No	Yes	No	Both
de Graaf et al. [11]	2010	The Netherlands	No	Yes	[^99mTc]Tc-Meb	36	No	No	No	Yes	Both
de Graaf et al. [10]	2010	The Netherlands	No	Yes	[^99mTc]Tc-Meb	55	No	Yes	Yes	Yes	Major
Dinant et al. [24]	2007	The Netherlands	Yes	Yes	[^99mTc]Tc-Meb	46	Yes	Yes	Yes	No	Both
Franken et al. [25]	2020	The Netherlands	No	Yes	[^99mTc]Tc-Meb	191	Yes	Yes	Yes	No	Both
Fujioka et al. [26]	1999	Japan	No	No	[^99mTc]Tc-GSA	15	Yes	No	Yes	No	Both
Guiu et al. [27]	2017	France	No	Yes	[^99mTc]Tc-Meb	9	Yes	Yes	Yes	Yes	Major
Hayashi et al. [28]	2015	Japan	No	Yes	[^99mTc]Tc-GSA	133	Yes	Yes	Yes	No	Major
Hino et al. [29]	1997	Japan	No	No	[^99mTc]Tc-Sn colloid	47	Yes	Yes	No	No	Both
Hirai et al. [30]	2003	Japan	No	Yes	[^99mTc]Tc-GSA	30	No	Yes	No	Yes	Major
Hwang et al. [31]	1999	Japan	Yes	Yes	[^99mTc]Tc-GSA	75	No	Yes	No	No	Both^2,3
Iimuro et al. [32]	2010	Japan	No	No	[^99mTc]Tc-GSA	32	No	No	Yes	Yes	Both
Jansen et al. [33]	1990	The Netherlands	No	No	[^99mTc]Tc-colloid	11	No	No	No	Yes	Both
Kaibori et al. [34]	2008	Japan	Yes	Yes	[^99mTc]Tc-GSA	191	Yes	Yes	No	No	Both
Kamohara et al. [35]	2011	Japan	No	No	[^99mTc]Tc-GSA	180	No	Yes	Yes	No	NR⁴
Kato et al. [36]	2018	Japan	No	Yes	[^99mTc]Tc-GSA	100	No	Yes	No	Yes	Both
Katsuramaki et al. [37]	2003	Japan	No	Yes	[^99mTc]Tc-GSA	63	No	Yes	Yes	No	Both
Kawamura et al. [38]	2008	Japan	No	No	[^99mTc]Tc-GSA	99	No	Yes	No	Yes	Both
Kim et al. [39]	1997	Japan	No	Yes	[^99mTc]Tc-GSA	30	Yes	Yes	Yes	No	Both
Kokudo et al. [40]	2002	Japan	No	Yes	[^99mTc]Tc-GSA	111	No	Yes	Yes	No	Minor
Kwon et al. [41]	1995	Japan	No	Yes	[^99mTc]Tc-GSA	36	No	No	No	Yes	Both²
Kwon et al. [42]	1997	Japan	No	Yes	[^99mTc]Tc-GSA	90	Yes	No	No	No	Both²
Kwon et al. [43]	2001	Japan	No	Yes	[^99mTc]Tc-GSA	47	Yes	No	No	Yes	Both²
Kwon et al. [44]	2004	Japan	No	No	[^99mTc]Tc-GSA	32	Yes	No	No	Yes	Both
Kwon et al. [45]	2004	Japan	No	No	[^99mTc]Tc-GSA	152	Yes	Yes	No	No	Both²
Kwon et al. [46]	2006	Japan	No	Yes	[^99mTc]Tc-GSA	178	Yes	No	No	Yes	Both²
Li et al. [47]	2003	Japan	Yes	No	[^99mTc]Tc-GSA	44	No	No	No	Yes	Both⁴
Mao et al. [48]	2015	China	Yes	No	[^99mTc]Tc-GSA	69	No	Yes	Yes	Yes	Both
Mitsumori et al. [49]	1998	Japan	No	No	[^99mTc]Tc-GSA	20	No	Yes	No	Yes	Both
Nakamura et al. [50]	2018	Japan	No	Yes	[^99mTc]Tc-GSA	218	No	Yes	No	No	Both
Nakano et al. [51]	1999	Japan (and France)	No	Yes	[^99mTc]Tc-GSA	18	No	Yes	Yes	Yes	Major⁵
Nakano et al. [52]	1999	Japan (and France)	No	Yes	[^99mTc]Tc-GSA	64	No	No	Yes	Yes	Both³
Namieno et al. [53]	1997	Japan	Yes	No	[^99mTc]Tc-PMT	8	Yes	No	No	Yes	Both
Nanashima et al. [54]	2004	Japan	No	No	[^99mTc]Tc-GSA	140	No	Yes	Yes	No	Both²
Nanashima et al. [55]	2007	Japan	No	Yes	[^99mTc]Tc-GSA	185	No	Yes	Yes	No	Both
Nanashima et al. [56]	2010	Japan	No	Yes	[^99mTc]Tc-GSA	250	No	Yes	Yes	No	Both
Nanashima et al. [57]	2013	Japan	No	No	[^99mTc]Tc-GSA	442	No	Yes	Yes	No	Both
Nanashima et al. [58]	2013	Japan	No	No	[^99mTc]Tc-GSA	67	No	Yes	Yes	No	Both²
Nanashima et al. [59]	2020	Japan	No	No	[^99mTc]Tc-GSA	229	No	Yes	Yes	No	Both
Nishikawa et al. [60]	2015	Japan	No	Yes	[^99mTc]Tc-GSA	213	Yes	No	Yes	No	Both
Nishiyama et al. [61]	2003	Japan	No	No	[^99mTc]Tc-GSA	20	Yes	No	No	No	Major
Nitta et al. [62]	2019	Japan	No	Yes	[^99mTc]Tc-GSA	60	No	Yes	Yes	Yes	Both
Okabayashi et al. [63]	2017	Japan	Yes	Yes	[^99mTc]Tc-GSA	185	Yes	Yes	Yes	Yes	Both
Okabe et al. [64]	2014	Japan	Yes	Yes	[^99mTc]Tc-GSA	625	No	Yes	No	No	Both²
Olthof et al. [65]	2017	The Netherlands	No	Yes	[^99mTc]Tc-Meb	116	Yes	Yes	Yes	No	Major
Otsuki et al. [66]	1997	Japan	Yes	No	[¹¹C]C-Met	11	Yes	No	No	No	Major
Rassam et al. [67]	2019	The Netherlands	No	Yes	[^99mTc]Tc-Meb	71	Yes	Yes	Yes	No	Both
Satoh et al. [68]	2003	Japan	No	No	[^99mTc]Tc-GSA	57	Yes	Yes	No	No	Both
Serenari et al.⁶ [69]	2018	Argentina	No	Yes	[^99mTc]Tc-Meb	20	Yes	Yes	No	No	Major
Serenari et al. [70]	2019	Italy	No	Yes	[^99mTc]Tc-Meb	27	No	Yes	No	No	Major
Shimizu et al. [71]	2010	Japan	Yes	No	[^99mTc]Tc-GSA	86	No	No	No	Yes	Both²
Sparrelid et al .[72]	2017	Sweden	Yes	No	[^99mTc]Tc-Meb	9	No	No	No	Yes	Major
Sugai et al. [73]	2000	Japan	No	No	[^99mTc]Tc-GSA	11	No	Yes	Yes	Yes	Major
Sumiyoshi et al. [74]	2016	Japan	No	No	[^99mTc]Tc-GSA	30	No	Yes	No	Yes	Major
Sumiyoshi et al. [75]	2018	Japan	No	Yes	[^99mTc]Tc-GSA	13	Yes	Yes	Yes	No	Both³
Takeuchi et al. [76]	1999	Japan	No	Yes	[^99mTc]Tc-GSA	40	Yes	No	Yes	Yes	Both
Tanabe et al. [77]	1989	Japan	No	No	[¹⁹⁸Au]Au colloid + [^99mTc]Tc-Sn colloid	21	Yes	No	Yes	No	Both
Tanaka et al. [78]	1999	Japan	No	No	[^99mTc]Tc-GSA	44	No	No	No	Yes	Both
Tanaka et al. [79]⁷	2013	Japan	Yes	Yes	[^99mTc]Tc-GSA	247	Yes	Yes	No	No	Major
Tanaka et al. [80]	2015	Japan	No	No	[^99mTc]Tc-GSA	64	No	No	No	Yes	Both
Tanoue et al. [81]	2019	Japan	No	No	[^99mTc]Tc-GSA	247	No	Yes	Yes	Yes	Both
Truant et al. [82]	2016	France	No	No	[^99mTc]Tc-Meb	5	Yes	Yes	No	Yes	Major
Truant et al. [83]	2017	France	Yes	Yes	[^99mTc]Tc-Meb	100	Yes	Yes	No	Yes	Major
Uetake et al. [84]	1999	Japan	No	No	[^99mTc]Tc-GSA	13	No	No	Yes	Yes	Both
van den Esschert et al. [85]	2009	The Netherlands	No	Yes	[^99mTc]Tc-Meb	23	No	No	No	Yes	Major
Wakamatsu et al. [86]	2010	Japan	Yes	Yes	[^99mTc]Tc-GSA	70	No	No	No	Yes	Minor
Yamao et al. [87]	2019	Japan	No	Yes	[^99mTc]Tc-GSA	283	Yes	No	Yes	No	NR^3,4
Yano et al. [88]	2017	Japan	No	No	[^99mTc]Tc-GSA	200	No	Yes	Yes	Yes	Both
Yano et al. [89]	2018	Japan	No	Yes	[^99mTc]Tc-GSA	165	Yes	No	No	No	Both
Yoshida et al. [90]	2012	Japan	No	No	[^99mTc]Tc-GSA	256	No	Yes	No	Yes	Both
Yoshida et al. [91]	2014	Japan	No	Yes	[^99mTc]Tc-GSA	95	No	No	No	Yes	Both²
Yumoto et al. [92]	1994	Japan	Yes	No	[^99mTc]Tc-GSA	26	Yes	Yes	No	Yes	Both²
Yumoto et al. [93]	2010	Japan	No	Yes	[^99mTc]Tc-GSA	101	Yes	Yes	No	Yes	Both

NMT nuclear medicine test, [^99mTc]Tc-Meb ^99mTc-labeled mebrofenin, [^99mTc]Tc-GSA ^99mTc-labeled galactosyl human serum albumin, [¹⁸F]FDG [¹⁸F]fluorodeoxyglucose, [^99mTc]Tc-Sn colloid ^99mTc-labeled sulfur colloid, [^99mTc]Tc-colloid ^99mTc-labeled colloid, [^99mTc]Tc-PMT ^99mTc-labeled pyridoxyl-5-methyltryptophan, [¹¹C]C-Met L-[methyl-¹¹C]-methionine, [¹⁹⁸Au]Au colloid + [^99mTc]Tc-Sn colloid radioactive colloidal gold and ^99mTc-labeled sulfur colloid
¹Including 88 patients from a prior study from Chapelle et al. [19] to whom they compare the results to and conduct new analyses on these patients
²Both major and minor surgery but analyzed separately in the paper
³Includes other procedures with the purpose to remove diseased liver parenchyma as well, not only liver resection
⁴The type of liver resection was not defined explicitly
⁵Pancreaticoduodenectomy with reconstructive pancreaticojejunostomy and hepaticojejunostomy, classified as major surgery
⁶Hepatobiliary scintigraphy performed before stage 2 of the ALPPS procedure
⁷Abstract

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