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Table 4 Mouse dosimetry of [177Lu]Lu-1C1m-Fc. These estimates come from mouse TIACs calculated from source organ time-activity curves

From: 177Lu radiolabeling and preclinical theranostic study of 1C1m-Fc: an anti-TEM-1 scFv-Fc fusion protein in soft tissue sarcoma

Source organ

Mouse average organ mass (g)

Average TIAC (MBq·h/MBq)

Absorbed dose (mGy/MBq)

Tumor SK-N-AS

0.16

3.91

1.82E+03

Liver

1.28

30.42

2.23E+03

Kidneys

0.33

2.04

7.05E+02

Lung

0.15

0.71

5.39E+02

Spleen

0.09

1.12

1.20E+03

Heart

0.20

0.33

3.63E+02

Stomach

0.10

0.55

1.15E+03

Small intestine

1.38

2.73

4.38E+02

Colon

0.87

1.74

3.28E+02

Bladder

0.10

0.13

3.16E+02

Uterus*

0.08

1.66

1.5 E+03

Total body

20.19

98.78

4.25E+02

  1. *The uterus is not part of the source/target organ in the murine model of the OLINDA/EXM 2.1 software. Specific dosimetry was obtained with the sphere model of the OLINDA/EXM 2.1 where the organ-specific average mass and TIAC were applied