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Fig. 2 | EJNMMI Research

Fig. 2

From: [18F]FEPPA PET imaging for monitoring CD68-positive microglia/macrophage neuroinflammation in nonhuman primates

Fig. 2

Representative [18F]FEPPA PET brain image of a rhesus macaque (R1) with allogeneic iPSC-mDA. Visual asymmetry in uptake is detected in the putamen of monkeys with allogeneic grafts. Images were overlayed on the MRI acquired during RT-IMRI delivery of the iPSC-mDA. Arrow in sagittal slice points to the cannula used for cell delivery. Arrows in coronal/axial slice point to the contralateral (left, black arrow) and ipsilateral (right, white arrow) putamen. The red overlay in the MRI is representative of the allogeneic iPSC-mDA graft and was utilized for visualization of [18F]FEPPA binding

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