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Table 2 Probe evaluation in relation to pathology

From: A DROP-IN beta probe for robot-assisted 68Ga-PSMA radioguided surgery: first ex vivo technology evaluation using prostate cancer specimens

Pt #

Probe evaluation

Pathologic evaluation

Injected activity [MBq]

Total activity left at time of scanning [MBq] and injection-surgery time interval [min]

S/B prostate tumor*

S/B PET positive LNs

Extra-capsular tumor spread

Positive resection margins

Shortest tumor-border distance [mm]

Tumor in PET Positive LNs

Tumor stage

1

68

11 (180)

107/14 = 7.6

N.A.

Yes

Yes

0

N.A.

pT3aN0 R1

2

88

15 (170)

40/16 = 2.5

N.A.

No

No

> 3

N.A.

pT2N0 R0

3

76

13 (175)

108/15 = 7.2

50/8 = 6.3 (ExR), 34/10 = 3.4 (ObR)

Yes

No

< 1

Yes (ExR), no (ObR)

pT3bN1 R0

4

97

32 (110)

88/40 = 2.2

N.A.

Yes

No

> 1.5

N.A.

pT3bN0 R0

5

65

14 (150)

108/15 = 7.2

N.A.

No

No

< 0.5

N.A.

pT2N0 R0

6

62

18 (120)

247/45 = 5.5

N.A.

Yes

No

< 0.5

N.A.

pT3aN1 R0

7

23

7 (120)

35/7 = 5.0

20/3 = 6.7 (ObL), 9/3 = 3.0 (ExR)

Yes

Yes

0

Yes(ObL), yes (ExR)

pT3bN1 R1

  1. Pt # patient number, S/B signal to background, N.A. not applicable, ExR external iliac right, ObR obturator right, ObL obturator left
  2. *As measured on the surface of the resected specimen. PET negative lymph nodes that were excised are not added in the table for clarity sake, since no sign of elevated tracer uptake was found in none of them with the probe either