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Table 2 Treatment dose data for patient dogs with spontaneous intra-axial masses

From: Yttrium-90 radioembolization as a possible new treatment for brain cancer: proof of concept and safety analysis in a canine model

 

P1

P2

P3

P4

P5* (extended)

P5* (extended)

P5* (actual)

 

First diagnosis (days before treatment)

16

35

35

33

28

  
 

Pre-treatment diagnosis

Vascular neoplasm vs vascular anomaly

Astrocytoma

Low-grade glioma

Glial neoplasm

Astrocytoma

  
 

Infused activity (GBq)

0.0183

0.0478

0.0351

0.0414

0.0486

 

Treatment days post-calibration

11

5

10

5

8

  
 

Volume of embolic (mL)

0.0014

0.00076

0.0021

0.00066

0.0017

  
 

Pre-treatment mass vol (mL)

2.76

5.82

3.53

8.66

8.48

 

Single compartment dose (Gy)

34.9

63.7

45

45.2

62.2

 

Dosimetry method

PET/CT

PET/CT

PET/CT

PET/CT

PET/CT

MicroCT

MicroCT

Mass

Mean dose (Gy)

45.5

57.6

58.1

45.4

64.1

76.7

11.3

D10 (Gy)

95.2

122.9

91.5

94.8

137.0

131.4

19.3

D30 (Gy)

58.6

70.2

70.8

54.9

80.0

80.8

11.9

D50 (Gy)

35.7

37.6

55.8

36.1

52.6

59.4

8.73

D70 (Gy)

22.6

20.2

41.6

24.2

27.9

44.8

6.58

D90 (Gy)

8.5

10.0

26.9

8.1

7.2

30.6

4.49

V30

58.3

55.9

85.4

60.4

68.9

90.6

3.28

V50

37.2

40.6

57.8

34.5

52.6

62.4

0.96

V60

28.9

34.9

44.0

26.8

43.5

49.3

0.64

V80

16.5

26.3

20.3

15.8

30.0

30.6

0.34

V100

9.1

19.0

6.4

8.4

19.3

10.3

0.22

Hemisphere

Mean dose (Gy)

33.8

65.3

41.1

45.0

61.4

41.4

6.08

V20

54.8

74.6

68.2

65.5

77.5

63.1

3.39

V30

40.8

66.4

57.6

50.8

67.1

49.8

1.21

V50

23.0

52.2

37.1

33.6

49.8

28.8

0.39

V60

17.3

44.7

27.7

27.3

41.7

21.5

0.27

Cortex

Mean dose (Gy)

15.4

27.6

19.2

16.7

33.3

V20

24.1

33.3

32.6

24.1

43.8

V30

17.7

28.2

25.6

17.7

36.5

V50

10.1

21.3

15.3

10.7

25.5

V60

7.4

18.0

11.3

8.3

21.0

 

T:N

2.96

2.08

3.02

2.71

1.93

  1. *P5 expired 15 h post-treatment. The “Actual” column lists the absorbed doses delivered at the time of expiration. P5 “Extended” represents the absorbed doses that would have been delivered had the dog survived
  2. Determined from post-mortem histopathology, in all other animals, the diagnosis is based on pre-treatment imaging
  3. T:N has been calculated as the ratio of the absorbed dose to the tumor compared to normal cortical brain tissue