Fig. 7
Gross pathology and microdosimetry for P5. a Pre-treatment T2 FLAIR 1 month prior to therapy. b Formalin-fixed gross pathologic example of the involved hemisphere with significant central tumor necrosis. c Microdosimetry showing the absorbed dose distribution in dog P5 if the dog had survived. At the time of death, only 15% of the absorbed doses shown had been delivered based on the half-life of 90Y. d Post-explant microCT showing the gross distribution of glass microspheres. the image is a maximum intensity projection of 100 microCT slices with a combined thickness of 900 μm. A preference for deposition in the peri-necrotic region of the tumor can be seen (white arrows). Occasional filling of end arterioles/capillaries with microspheres can be visualized (red arrow)