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Table 3 Tissue distribution of radioactivity in mice after intravenous injection of [18F]MC225

From: Automated synthesis, preclinical toxicity, and radiation dosimetry of [18F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier

  Injected dose/g tissue (%) *
5 min 15 min 30 min 60 min 180 min 360 min
Blood 0.70 ± 0.09 0.55 ± 0.19 0.73 ± 0.13 0.87 ± 0.25 0.97 ± 0.09 0.64 ± 0.04
Heart 2.82 ± 0.32 1.54 ± 0.10 1.54 ± 0.23 1.23 ± 0.29 1.28 ± 0.12 0.86 ± 0.12
Lung 17.73 ± 5.34 7.35 ± 0.49 6.17 ± 0.71 3.28 ± 0.87 1.88 ± 0.12 1.11 ± 0.13
Liver 9.74 ± 0.86 12.41 ± 0.28 11.99 ± 0.19 10.01 ± 1.31 4.51 ± 0.21 2.98 ± 0.51
Pancreas 10.12 ± 0.29 15.17 ± 1.32 22.85 ± 2.69 19.13 ± 3.08 37.36 ± 1.87 33.34 ± 5.05
Spleen 4.85 ± 0.77 4.34 ± 1.04 4.83 ± 0.30 2.64 ± 0.62 2.24 ± 0.39 0.94 ± 0.17
Kidney 12.40 ± 1.55 9.06 ± 0.50 6.88 ± 1.88 4.46 ± 0.73 2.55 ± 0.78 2.35 ± 0.56
Stomach 3.14 ± 0.64 3.03 ± 0.18 3.66 ± 1.02 5.69 ± 1.10 3.90 ± 1.35 2.69 ± 0.75
Small intestine 3.57 ± 0.24 4.13 ± 0.24 6.37 ± 0.75 9.43 ± 2.22 12.40 ± 1.01 7.30 ± 0.55
Large intestine 2.19 ± 0.32 2.70 ± 0.55 2.62 ± 0.15 3.52 ± 1.68 8.33 ± 3.57 13.00 ± 1.50
Testis 0.91 ± 0.28 0.87 ± 0.11 1.16 ± 0.08 1.11 ± 0.31 1.76 ± 0.14 1.49 ± 0.27
Muscle 1.84 ± 0.30 1.26 ± 0.17 1.33 ± 0.05 1.28 ± 0.43 0.80 ± 0.05 0.50 ± 0.09
Bone 1.65 ± 0.12 1.51 ± 0.16 2.16 ± 0.15 1.52 ± 0.22 2.46 ± 0.17 3.38 ± 1.03
Brain 1.24 ± 0.09 1.27 ± 0.29 1.14 ± 0.04 0.93 ± 0.11 0.81 ± 0.05 0.53 ± 0.05
  1. *Mean ± S.D. (n = 4)