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Table 3 Tissue distribution of radioactivity in mice after intravenous injection of [18F]MC225

From: Automated synthesis, preclinical toxicity, and radiation dosimetry of [18F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier

 

Injected dose/g tissue (%) *

5 min

15 min

30 min

60 min

180 min

360 min

Blood

0.70 ± 0.09

0.55 ± 0.19

0.73 ± 0.13

0.87 ± 0.25

0.97 ± 0.09

0.64 ± 0.04

Heart

2.82 ± 0.32

1.54 ± 0.10

1.54 ± 0.23

1.23 ± 0.29

1.28 ± 0.12

0.86 ± 0.12

Lung

17.73 ± 5.34

7.35 ± 0.49

6.17 ± 0.71

3.28 ± 0.87

1.88 ± 0.12

1.11 ± 0.13

Liver

9.74 ± 0.86

12.41 ± 0.28

11.99 ± 0.19

10.01 ± 1.31

4.51 ± 0.21

2.98 ± 0.51

Pancreas

10.12 ± 0.29

15.17 ± 1.32

22.85 ± 2.69

19.13 ± 3.08

37.36 ± 1.87

33.34 ± 5.05

Spleen

4.85 ± 0.77

4.34 ± 1.04

4.83 ± 0.30

2.64 ± 0.62

2.24 ± 0.39

0.94 ± 0.17

Kidney

12.40 ± 1.55

9.06 ± 0.50

6.88 ± 1.88

4.46 ± 0.73

2.55 ± 0.78

2.35 ± 0.56

Stomach

3.14 ± 0.64

3.03 ± 0.18

3.66 ± 1.02

5.69 ± 1.10

3.90 ± 1.35

2.69 ± 0.75

Small intestine

3.57 ± 0.24

4.13 ± 0.24

6.37 ± 0.75

9.43 ± 2.22

12.40 ± 1.01

7.30 ± 0.55

Large intestine

2.19 ± 0.32

2.70 ± 0.55

2.62 ± 0.15

3.52 ± 1.68

8.33 ± 3.57

13.00 ± 1.50

Testis

0.91 ± 0.28

0.87 ± 0.11

1.16 ± 0.08

1.11 ± 0.31

1.76 ± 0.14

1.49 ± 0.27

Muscle

1.84 ± 0.30

1.26 ± 0.17

1.33 ± 0.05

1.28 ± 0.43

0.80 ± 0.05

0.50 ± 0.09

Bone

1.65 ± 0.12

1.51 ± 0.16

2.16 ± 0.15

1.52 ± 0.22

2.46 ± 0.17

3.38 ± 1.03

Brain

1.24 ± 0.09

1.27 ± 0.29

1.14 ± 0.04

0.93 ± 0.11

0.81 ± 0.05

0.53 ± 0.05

  1. *Mean ± S.D. (n = 4)