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Fig. 3 | EJNMMI Research

Fig. 3

From: Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer

Fig. 3

uPAR in rheumatoid arthritis. a uPAR on neo-angiogenic endothelium support the influx of inflammatory cells. b Neutrophils secrete uPA and uPAR-D2/3 further escalating the inflammation. c The uPA interacts via autocrine and paracrine methods with neutrophils, fibroblast-like synoviocytes, macrophages and chondrocytes, activating invasive, and proliferative pathways in these cells. d uPAR on osteoclasts promotes bone destruction. uPAR is represented by the red 3-domain structure as described in Fig. 1 on the cell membrane of uPAR expressing cells and uPA by the green structure in the extracellular matrix and bound to uPAR

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