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Fig. 2 | EJNMMI Research

Fig. 2

From: Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer

Fig. 2

uPAR in atherosclerosis. a Monocyte extravasation across the endothelium lesions is dependent on uPAR. b Upon interaction with uPA these monocytes differentiate into macrophages, eventually resulting in cholesterol filled monocyte-derived macrophages. c uPA released from macrophages interacts with uPAR on synthetic smooth muscle cells stimulating their migration. d Localized uPAR overexpression in an atherosclerotic plaque increases the risk of rupture. uPAR is represented by the red 3-domain structure as described in Fig. 1 on the cell membrane of uPAR expressing cells and uPA by the green structure in the extracellular matrix and bound to uPAR

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