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Fig. 5 | EJNMMI Research

Fig. 5

From: Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis

Fig. 5

Mitochondrial/ER ultrastructure and bioenergetics activity in skeletal muscles. a, b Electron microscopy representative images of control and SOD1G93A quadriceps (n = 3). In both panels, red arrows show mitochondria while yellow arrows show ER ultrastructural profiles. ce Western blot analysis and relative densitometry quantitative analyses of Mfn2, Drp1, and Calnexin in the two groups. f, g ATP synthesis and oxygen consumption rate stimulated by pyruvate/malate in control (green column) and SOD1G93A (red column) of isolated mitochondria. h Complex I activity in isolated mitochondria form control (green column) and SOD1G93A muscles (red column) studied by the FeCN reduction in the presence of NADH. Data are expressed as mean ± SD, n = 3 for each group. Student t test for unpaired data was used for statistical evaluation

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