| |
Pearson’s r
|
ICC
|
Bias (%)
|
|---|
|
Ligand
|
Model
|
Region 1
|
Region 2
|
Region 1
|
Region 2
|
Bias 1
|
Bias 2
|
|
Invasive
|
|
[11C]PBR28
|
2TCM
|
1.00
|
1.00
|
0.99
|
1.00
|
2.01
|
1.19
|
|
Logan
|
1.00
|
1.00
|
0.99
|
0.99
|
0.47
|
− 0.27
|
|
MA1
|
1.00
|
0.99
|
0.95
|
0.97
|
10.07
|
9.55
|
|
[11C]PK11195
|
2TCM
|
1.00
|
0.98
|
1.00
|
0.98
|
1.16
|
0.69
|
|
Logan
|
1.00
|
0.97
|
0.99
|
0.94
|
− 3.40
|
− 5.88
|
|
MA1
|
0.99
|
0.95
|
0.97
|
0.89
|
4.99
|
9.54
|
|
Non-invasive
|
|
[11C]AZ10419369
|
SRTM
|
1.00
|
1.00
|
1.00
|
1.00
|
-0.17
|
0.13
|
|
ref Logan
|
0.99
|
0.99
|
0.93
|
0.91
|
− 2.95
|
− 3.55
|
|
MRTM2
|
0.97
|
0.96
|
0.86
|
0.80
|
− 3.94
|
− 5.35
|
|
[11C]SCH23390
|
SRTM
|
1.00
|
1.00
|
1.00
|
1.00
|
0.24
|
0.53
|
|
ref Logan
|
0.99
|
0.99
|
0.88
|
0.96
|
− 5.26
|
− 4.31
|
|
MRTM2
|
1.00
|
1.00
|
0.98
|
0.99
|
− 2.07
|
− 2.17
|
- Region 1 corresponds to the occipital cortex for the radioligand [11C]AZ10419369, the striatum for [11C]SCH23390 and the thalamus for both (R)-[11C]PK11195 and [11C]PBR28. Region 2 corresponds to the frontal cortex for all four radioligands which were used in this study. Abbreviations: 2TCM two-tissue compartmental model, Logan invasive Logan plot, MA1 Ichise’s Multilinear Analysis 1, SRTM simplified reference tissue model, ref Logan reference tissue Logan plot, MRTM2 Ichise's Multilinear Reference Tissue Model 2 (MRTM2), ICC intra-class correlation coefficient, Pearson’s r Pearson’s correlation coefficient
