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Table 1 Correspondence between kinfitr and PMOD

From: Kinfitr — an open-source tool for reproducible PET modelling: validation and evaluation of test-retest reliability

  Pearson’s r ICC Bias (%)
Ligand Model Region 1 Region 2 Region 1 Region 2 Bias 1 Bias 2
Invasive
[11C]PBR28 2TCM 1.00 1.00 0.99 1.00 2.01 1.19
Logan 1.00 1.00 0.99 0.99 0.47 − 0.27
MA1 1.00 0.99 0.95 0.97 10.07 9.55
[11C]PK11195 2TCM 1.00 0.98 1.00 0.98 1.16 0.69
Logan 1.00 0.97 0.99 0.94 − 3.40 − 5.88
MA1 0.99 0.95 0.97 0.89 4.99 9.54
Non-invasive
[11C]AZ10419369 SRTM 1.00 1.00 1.00 1.00 -0.17 0.13
ref Logan 0.99 0.99 0.93 0.91 − 2.95 − 3.55
MRTM2 0.97 0.96 0.86 0.80 − 3.94 − 5.35
[11C]SCH23390 SRTM 1.00 1.00 1.00 1.00 0.24 0.53
ref Logan 0.99 0.99 0.88 0.96 − 5.26 − 4.31
MRTM2 1.00 1.00 0.98 0.99 − 2.07 − 2.17
  1. Region 1 corresponds to the occipital cortex for the radioligand [11C]AZ10419369, the striatum for [11C]SCH23390 and the thalamus for both (R)-[11C]PK11195 and [11C]PBR28. Region 2 corresponds to the frontal cortex for all four radioligands which were used in this study. Abbreviations: 2TCM two-tissue compartmental model, Logan invasive Logan plot, MA1 Ichise’s Multilinear Analysis 1, SRTM simplified reference tissue model, ref Logan reference tissue Logan plot, MRTM2 Ichise's Multilinear Reference Tissue Model 2 (MRTM2), ICC intra-class correlation coefficient, Pearson’s r Pearson’s correlation coefficient