|  | IC50 (nM) of uptake inhibition | Selectivity factor | ||
---|---|---|---|---|---|
Platelets | SK-N-SH | IC50 ratio | |||
[3H]Serotonin | [125I]MIBG | [125I]MIBG | |||
SSRIs | Alaproclate | 516 | 38 | 43420 | 1158 |
Citalopram | 32 | 7.8 | 11940 | 1521 | |
Fluvoxamine | 30 | 9.3 | 2339 | 252 | |
Fluoxetine | 115 | 32 | 1270 | 40 | |
Norfluoxetine | 107 | 24 | 2760 | 115 | |
Paroxetine | 0.6 | 0.2 | 10 | 45 | |
Sertraline | 41 | 36 | 3301 | 91 | |
TCAs | Clomipramine | 18 | 7 | 176 | 24 |
Imipramine | 118 | 104 | 82 | 0.8 | |
Desipramine | 648 | 744 | 5 | 0.007 | |
TeCA | Maprotiline | n.d. | 1000–10,000 | 39 | 0.04–0.004 |