Skip to main content
EJNMMI Research
Fig. 5 | EJNMMI Research

Fig. 5

From: Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake

Fig. 5

Inhibition of [125I]MIBG uptake by SSRIs and tricyclic antidepressants in human platelets and cultured SK-N-SH neuroblastoma cells. [125I]MIBG uptake in isolated human platelets is depicted by open symbols (Δ), and [125I]MIBG uptake in cultured human SK-N-SH neuroblastoma cells by closed symbols (■). Samples were incubated at 37 °C for 4 h with a substrate concentration of 10−8 M. MIBG uptake is expressed as the percentage of control without inhibitor. Data represent mean ± SD (n ≥ 3)

Back to article page