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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake

Fig. 1

Uptake of MIBG by NET in neuroblastoma cells and SERT in platelets. Norepinephrine (in green) is the natural substrate of the norepinephrine transporter (NET), serotonin (in red) of the serotonin transporter (SERT). Both monoamine transporters are capable of intracellular transport of MIBG (in blue). aFor all monoamine transporter inhibitors, the selectivity factor was calculated from the ratio of the dissociation constants (KD) for serotonin at SERT and norepinephrine at NET [4]. Selective serotonin reuptake inhibitors (SSRIs) are depicted in italics

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