Table 1 Experimental information for [18F]FNDP PET scans (baseline and blocking) in baboons
From: PET imaging of soluble epoxide hydrolase in non-human primate brain with [18F]FNDP
Animal | Study | Days after baseline scan | [18F]FNDP dose (MBq) | Specific activity, TBq/μmol (Ci/μmol) | FNDP carrier dose, (μg/kg) | AR-9281 dose (mg/kg) |
|---|---|---|---|---|---|---|
Baboon 1 | Baseline | - | 314.13 | 1.30 (35.2) | 3.2 × 10-3 | 0 |
Baboon 2 | Baseline | - | 247.90 | 2.63 (71.2) | 1.3 × 10-3 | 0 |
Baboon 3 | Baseline | - | 295.26 | 3.65 (98.6) | 1.1 × 10-3 | 0 |
Blocking 1 | 27 | 283.42 | 2.87 (77.5) | 1.3 × 10-3 | 1.0 | |
Blocking 2 | 69 | 294.89 | 2.96 (79.9) | 1.3 × 10-3 | 0.1 | |
Blocking 3 | 112 | 284.16 | 2.13 (57.5) | 1.8 × 10-3 | 0.02 |