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Fig. 5 | EJNMMI Research

Fig. 5

From: Simultaneous in vivo PET/MRI using fluorine-18 labeled Fe3O4@Al(OH)3 nanoparticles: comparison of nanoparticle and nanoparticle-labeled stem cell distribution

Fig. 5

Bone uptake after injection of 18F-labeled Fe3O4@Al(OH)3 NPs or mMSCs labeled with these NPs. After acquisition of the last PET/MRI scan, a CT scan was acquired for a subgroup of mice to visualize the bone structure. a After injection of either RL NPs or mMSCs labeled with RL NPs (mMSCs + RL NPs), 18F uptake was visualized in the bones of the mice on the maximum intensity projection (MIP) images and overlays of CT-based bone mask and 1 h static 18F-PET (SUV = 0–9). b Corresponding quantification (mean standardized uptake values, SUVmean) confirms the gradual uptake in bone. Significant differences were found between both groups starting from 4 min post injection (PI) of the tracer (frame 5) based on a repeated measures two-way ANOVA with Bonferroni correction for multiple comparisons (4 min PI: p < 0.05, 5–11 min PI: p < 0.01, from 12 min PI on: p < 0.001)

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