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EJNMMI Research
Fig. 4 | EJNMMI Research

Fig. 4

From: Simultaneous in vivo PET/MRI using fluorine-18 labeled Fe3O4@Al(OH)3 nanoparticles: comparison of nanoparticle and nanoparticle-labeled stem cell distribution

Fig. 4

Whole-body MRI for localization of 18F-labeled Fe3O4@Al(OH)3 NPs or mMSCs labeled with these NPs. A dynamic contrast enhanced (DCE) MRI, 3D T2-weighted anatomical MRI, and T2 map were acquired to study the biodistribution of 18F-labeled Fe3O4@Al(OH)3 NPs (RL NPs) and mMSCs labeled with RL NPs (mMSCs + RL NPs) in comparison with the control group (injection of saline). a A characteristic hypointense liver can be seen on the 3D T2-weighted anatomical scans after the injection of the RL NPs as indicated by the white arrow. b The significant decrease in T2 values of the liver after injection of the RL NPs in comparison to baseline, the saline control and the mMSC + RL NPs group confirms the uptake of the NPs in the liver (one-way ANOVA with Bonferroni correction for multiple testing; ****p < 0. 0001). c DCE-MRI further confirms the uptake of RL NPs by the significant decrease in mean signal intensity in the liver 5 min after injection (p < 0.05 when compared to baseline; two-way repeated-measures ANOVA with Bonferroni correction)

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