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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: Simultaneous in vivo PET/MRI using fluorine-18 labeled Fe3O4@Al(OH)3 nanoparticles: comparison of nanoparticle and nanoparticle-labeled stem cell distribution

Fig. 1

Experimental overview. a After acquisition of baseline MRI scans, 18F-labeled Fe3O4@Al(OH)3 nanoparticles (radiolabeled; RL NPs) or mouse mesenchymal stem cells (mMSCs) labeled with such NPs (mMSCs + RL NPs) are injected intravenously (IV) during simultaneous PET/MRI acquisition to follow-up their respective short-term biodistribution over time. In the control group, saline or free [18F]NaF was injected. Afterwards, a small cohort of mice underwent CT imaging to visualize uptake in bones. Finally, animals were sacrificed; different organs were isolated and analyzed using the gamma-counter. b Biodistribution of non-RL (cold) NPs or mMSCs labeled with them was studied over a period of 7 days post-injection (PI) using both MRI and bioluminescence imaging (BLI) after the IV injection of the NPs/cells. c After IV injection of cold Fe3O4@Al(OH)3 nanoparticles or mMSCs labeled with them, blood samples were taken on day one and day seven PI to analyze the white blood cell (WBC) population. Control groups in b and c were injected with saline

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