Voxel-based comparison of [68Ga]Ga-RM2-PET/CT and [68Ga]Ga-PSMA-11-PET/CT with histopathology for diagnosis of primary prostate cancer

EJNMMI Research

Table 2 Overview of ROC analyses for ⁶⁸Ga-RM2-PET and ⁶⁸Ga-PSMA-11-PET with binary histoPET as reference

Patient No.	AUC RM2	[⁶⁸Ga]Ga-RM2 SUV threshold for a sensitivity ≥ 0.9 [g/ml]	Relative threshold for [⁶⁸Ga]Ga-RM2 (SUV/SUVmax)	Corresponding specificity (RM2)	AUC PSMA	Best absolute PSMA SUV threshold for a sensitivity ≥ 0.9 [g/ml]¹	Relative threshold for PSMA (SUV/SUVmax)¹	Corresponding specificity (PSMA)¹
1	0.80	1.91	0.14	0.62	0.76	1.58	0.24	0.48
2	0.84	1.38	0.31	0.63	0.86	1.68	0.21	0.55
3	0.71	1.12	0.24	0.34	0.89	11.49	0.21	0.72
4	0.69	1.61	0.09	0.18	0.56	1.19	0.21	0.31
5	0.72	2.14	0.32	0.46	0.80	1.37	0.36	0.52
6	0.85	2.98	0.30	0.64	0.83	5.35	0.34	0.79
7	0.93	3.35	0.29	0.87	0.95	1.93	0.46	0.81
8	0.89	1.95	0.38	0.68	0.89	2.01	0.29	0.67
Mean	0.80 ± 0.10	2.06 ± 0.77	0.25 ± 0.11	0.55 ± 0.20	0.82 ± 0.12	3.32 ± 3.56	0.29 ± 0.09	0.61 ± 0.16