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Table 1 Patient profiles

From: Tumour-to-liver ratio determined by [68Ga]Ga-DOTA-TOC PET/CT as a prognostic factor of lanreotide efficacy for patients with well-differentiated gastroenteropancreatic-neuroendocrine tumours

Characteristic

Value

Total number of patients

31

Age (year)

55.1 ± 15.5 (16.0–81.0)

Gender (M:F)

12:19

ECOG performance status

 0

8 (25.8%)

 1

23 (74.2%)

Primary tumour site

 Pancreas

17 (54.8%)

 Stomach

5 (16.1%)

 Small bowel

2 (6.5%)

 Rectum

4 (12.9%)

 Unknown

3 (9.7%)

Differentiation of tumour

 Well-differentiated

31 (100.0%)

NET WHO grade

 1

8 (25.8%)

 2

20 (64.5%)

 3

2 (6.5%)

 Unknown

1 (3.2%)

Median Ki-67 index (%)

7.5 (0.5–25.0)

Existence of carcinoid symptoms

8 (25.8%)

Previous treatment

 Surgery

14 (45.2%)

 Chemotherapy

4 (12.9%)

Hepatic tumour volume assessed by CT or MRI

 0–25%

15 (48.4%)

 > 25%

10 (32.2%)

 Unknown

6 (19.4%)

Best response after lanreotide therapy

 Partial response

1 (3.2%)

 Stable disease

28 (90.3%)

 Progressive disease

2 (6.5%)

Progression of disease after lanreotide therapy

20 (64.5%)

Median PFS after lanreotide therapy (months)

14.4 (1.3–34.9)

  1. ECOG Eastern Cooperative Oncology Group, NET neuroendocrine tumour, WHO World Health Organization, CT computed tomography, MRI magnetic resonance imaging, PFS progression-free survival