Synthesis of a novel 89Zr-labeled HER2 affibody and its application study in tumor PET imaging

Xu, Yuping; Wang, Lizhen; Pan, Donghui; Yan, Junjie; Wang, Xinyu; Yang, Runlin; Li, Mingzhu; Liu, Yu; Yang, Min

doi:10.1186/s13550-020-00649-7

EJNMMI Research

Table 1 Biodistribution of [⁸⁹Zr]Zr-DFO-MAL-Cys-MZHER2 in mice bearing tumors at different time points after administration (n = 4 per group)

From: Synthesis of a novel ⁸⁹Zr-labeled HER2 affibody and its application study in tumor PET imaging

Tissues (%IA/g)	SKOV-3							SKOV-3 Block	MCF-7
Tissues (%IA/g)	1 h	4 h	8 h	18 h	24 h	48 h	72 h	1 h	1 h
Blood	1.47 ± 0.47	0.52 ± 0.09	0.24 ± 0.10	0.16 ± 0.02	0.09 ± 0.01	0.04 ± 0.01	0.02 ± 0.00	1.03 ± 0.16	0.88 ± 0.19
Brain	0.73 ± 0.08	0.32 ± 0.06	0.28 ± 0.20	0.13 ± 0.03	0.10 ± 0.03	0.06 ± 0.01	0.03 ± 0.00	0.43 ± 0.05	0.34 ± 0.05
Heart	0.70 ± 0.24	0.55 ± 0.04	0.19 ± 0.08	0.17 ± 0.05	0.16 ± 0.07	0.10 ± 0.03	0.06 ± 0.01	0.62 ± 0.14	0.56 ± 0.06
Liver	2.03 ± 0.32	1.39 ± 0.38	0.63 ± 0.13	0.30 ± 0.06	0.17 ± 0.09	0.09 ± 0.03	0.05 ± 0.01	1.84 ± 0.39	1.65 ± 0.23
Spleen	1.47 ± 0.41	1.00 ± 0.27	0.68 ± 0.18	0.28 ± 0.09	0.20 ± 0.12	0.10 ± 0.03	0.06 ± 0.00	1.12 ± 0.10	0.92 ± 0.26
Lung	1.84 ± 0.50	1.27 ± 0.26	0.58 ± 0.14	0.35 ± 0.08	0.20 ± 0.05	0.10 ± 0.03	0.08 ± 0.01	0.68 ± 0.14	1.399 ± 0.14
Kidney	101.90 ± 11.31	145.33 ± 18.06	141.27 ± 6.21	146.57 ± 11.58	135.47 ± 6.71	128.47 ± 12.35	131.29 ± 20.36	175.83 ± 6.45	149.25 ± 15.52
Stomach	1.92 ± 0.31	1.19 ± 0.19	0.63 ± 0.22	0.36 ± 0.09	0.28 ± 0.07	0.17 ± 0.03	0.10 ± 0.02	1.16 ± 0.34	1.29 ± 0.12
Intestine	1.73 ± 0.27	1.16 ± 0.29	0.91 ± 0.43	0.57 ± 0.08	0.28 ± 0.04	0.13 ± 0.02	0.08 ± 0.01	1.89 ± 0.92	0.95 ± 0.11
Muscle	0.64 ± 0.12	0.44 ± 0.07	0.14 ± 0.02	0.09 ± 0.01	0.06 ± 0.01	0.03 ± 0.01	0.01 ± 0.00	0.58 ± 0.17	0.56 ± 0.08
Pancreas	1.49 ± 0.45	1.52 ± 0.28	0.82 ± 0.04	0.56 ± 0.05	0.38 ± 0.16	0.15 ± 0.03	0.06 ± 0.01	0.62 ± 0.14	1.38 ± 0.11
Bone	1.60 ± 0.33	1.36 ± 0.39	0.44 ± 0.02	0.36 ± 0.08	0.21 ± 0.10	0.15 ± 0.03	0.08 ± 0.02	0.71 ± 0.15	0.74 ± 0.10
Tumor	11.27 ± 1.55	10.95 ± 1.48	11.98 ± 1.24	9.82 ± 0.48	8.20 ± 0.82	5.80 ± 0.75	3.94 ± 0.21	2.18 ± 0.23	1.76 ± 0.31
Ratios
Tumor/blood	8.38 ± 3.73	18.28 ± 2.10	43.09 ± 3.55	77.06 ± 14.67	89.00 ± 12.89	144.13 ± 17.93	198.00 ± 12.77	2.15 ± 0.26	1.98 ± 035
Tumor/muscle	17.80 ± 3.08	21.23 ± 2.09	79.52 ± 18.40	127.88 ± 12.16	138.07 ± 18.63	257.06 ± 29.95	393.50 ± 38.18	3.78 ± 1.02	3.37 ± 0.86

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