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Table 1 Biodistribution of [89Zr]Zr-DFO-MAL-Cys-MZHER2 in mice bearing tumors at different time points after administration (n = 4 per group)

From: Synthesis of a novel 89Zr-labeled HER2 affibody and its application study in tumor PET imaging

Tissues (%IA/g)SKOV-3SKOV-3 BlockMCF-7
1 h4 h8 h18 h24 h48 h72 h1 h1 h
Blood1.47 ± 0.470.52 ± 0.090.24 ± 0.100.16 ± 0.020.09 ± 0.010.04 ± 0.010.02 ± 0.001.03 ± 0.160.88 ± 0.19
Brain0.73 ± 0.080.32 ± 0.060.28 ± 0.200.13 ± 0.030.10 ± 0.030.06 ± 0.010.03 ± 0.000.43 ± 0.050.34 ± 0.05
Heart0.70 ± 0.240.55 ± 0.040.19 ± 0.080.17 ± 0.050.16 ± 0.070.10 ± 0.030.06 ± 0.010.62 ± 0.140.56 ± 0.06
Liver2.03 ± 0.321.39 ± 0.380.63 ± 0.130.30 ± 0.060.17 ± 0.090.09 ± 0.030.05 ± 0.011.84 ± 0.391.65 ± 0.23
Spleen1.47 ± 0.411.00 ± 0.270.68 ± 0.180.28 ± 0.090.20 ± 0.120.10 ± 0.030.06 ± 0.001.12 ± 0.100.92 ± 0.26
Lung1.84 ± 0.501.27 ± 0.260.58 ± 0.140.35 ± 0.080.20 ± 0.050.10 ± 0.030.08 ± 0.010.68 ± 0.141.399 ± 0.14
Kidney101.90 ± 11.31145.33 ± 18.06141.27 ± 6.21146.57 ± 11.58135.47 ± 6.71128.47 ± 12.35131.29 ± 20.36175.83 ± 6.45149.25 ± 15.52
Stomach1.92 ± 0.311.19 ± 0.190.63 ± 0.220.36 ± 0.090.28 ± 0.070.17 ± 0.030.10 ± 0.021.16 ± 0.341.29 ± 0.12
Intestine1.73 ± 0.271.16 ± 0.290.91 ± 0.430.57 ± 0.080.28 ± 0.040.13 ± 0.020.08 ± 0.011.89 ± 0.920.95 ± 0.11
Muscle0.64 ± 0.120.44 ± 0.070.14 ± 0.020.09 ± 0.010.06 ± 0.010.03 ± 0.010.01 ± 0.000.58 ± 0.170.56 ± 0.08
Pancreas1.49 ± 0.451.52 ± 0.280.82 ± 0.040.56 ± 0.050.38 ± 0.160.15 ± 0.030.06 ± 0.010.62 ± 0.141.38 ± 0.11
Bone1.60 ± 0.331.36 ± 0.390.44 ± 0.020.36 ± 0.080.21 ± 0.100.15 ± 0.030.08 ± 0.020.71 ± 0.150.74 ± 0.10
Tumor11.27 ± 1.5510.95 ± 1.4811.98 ± 1.249.82 ± 0.488.20 ± 0.825.80 ± 0.753.94 ± 0.212.18 ± 0.231.76 ± 0.31
Ratios 
 Tumor/blood8.38 ± 3.7318.28 ± 2.1043.09 ± 3.5577.06 ± 14.6789.00 ± 12.89144.13 ± 17.93198.00 ± 12.772.15 ± 0.261.98 ± 035
 Tumor/muscle17.80 ± 3.0821.23 ± 2.0979.52 ± 18.40127.88 ± 12.16138.07 ± 18.63257.06 ± 29.95393.50 ± 38.183.78 ± 1.023.37 ± 0.86