Skip to main content

Table 4 Univariate and multivariate analysis of factors associated with overall survival and progression-free survival

From: The flow-metabolism ratio might predict treatment response and survival in patients with locally advanced esophageal squamous cell carcinoma

Characteristics

Overall survival

 

Progression-free survival

HR (95% CI)

p

 

HR (95% CI)

p

Univariate analysis

 Age (< 65 years/≥ 65 years)

4.541 (1.694–12.172)

0.003

2.414 (1.033–5.641)

0.042

 Gender (male/female)

0.841 (0.319–2.219)

0.727

0.689 (0.283–1.681)

0.414

 Location (upper/middle/lower)

0.812 (0.437–1.508)

0.509

0.710 (0.401–1.256)

0.239

 Length (< 5 cm/≥ 5 cm)

1.905 (0.773–4.697)

0.161

1.814 (0.807–4.078)

0.150

 Clinical stage (IIb/III)

2.975 (0.982–9.015)

0.054

2.405 (0.932–6.206)

0.070

 Response (OR/non-OR)

2.442 (0.973–6.126)

0.057

2.587 (1.096–6.109)

0.030

 BF

1.983 (0.811–4.852)

0.134

1.821 (0.787–4.214)

0.162

 BV

1.181 (0.489–2.853)

0.712

1.234 (0.552–2.762)

0.608

 TTP

1.507 (0.631–3.600)

0.335

1.681 (0.725–3.898)

0.226

 SUVmax

1.088 (0.458–2.587)

0.848

1.240 (0.555–2.769)

0.600

 MTV

1.308 (0.554–3.088)

0.540

1.780 (0.761–4.162)

0.183

 TLG

1.308 (0.554–3.088)

0.540

1.780 (0.761–4.162)

0.183

 FMR

3.092 (1.245–7.678)

0.015

2.829 (1.202–6.661)

0.017

Multivariate analysis

 Age(< 65 years/≥ 65 years)

7.446 (2.273–24.395)

0.001

2.592 (1.081–6.213)

0.033

 Clinical stage (IIb/III)

3.790 (1.104–13.013)

0.034

NA

0.245

 Response (OR/non-OR)

NA

0.867

NA

0.427

 FMR

2.914 (1.138–7.462)

0.026

3.009 (1.252–7.227)

0.014

  1. OR objective response, BF blood flow, BV blood volume, TTP time to peak, SUVmax maximum standardized uptake value, MTV metabolic tumor volume, TLG total lesion glycolysis, FMR flow-metabolism ratio, HR hazard ratio, 95% CI 95% confidence interval