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Table 4 Univariate and multivariate analysis of factors associated with overall survival and progression-free survival

From: The flow-metabolism ratio might predict treatment response and survival in patients with locally advanced esophageal squamous cell carcinoma

CharacteristicsOverall survival Progression-free survival
HR (95% CI)p HR (95% CI)p
Univariate analysis
 Age (< 65 years/≥ 65 years)4.541 (1.694–12.172)0.0032.414 (1.033–5.641)0.042
 Gender (male/female)0.841 (0.319–2.219)0.7270.689 (0.283–1.681)0.414
 Location (upper/middle/lower)0.812 (0.437–1.508)0.5090.710 (0.401–1.256)0.239
 Length (< 5 cm/≥ 5 cm)1.905 (0.773–4.697)0.1611.814 (0.807–4.078)0.150
 Clinical stage (IIb/III)2.975 (0.982–9.015)0.0542.405 (0.932–6.206)0.070
 Response (OR/non-OR)2.442 (0.973–6.126)0.0572.587 (1.096–6.109)0.030
 BF1.983 (0.811–4.852)0.1341.821 (0.787–4.214)0.162
 BV1.181 (0.489–2.853)0.7121.234 (0.552–2.762)0.608
 TTP1.507 (0.631–3.600)0.3351.681 (0.725–3.898)0.226
 SUVmax1.088 (0.458–2.587)0.8481.240 (0.555–2.769)0.600
 MTV1.308 (0.554–3.088)0.5401.780 (0.761–4.162)0.183
 TLG1.308 (0.554–3.088)0.5401.780 (0.761–4.162)0.183
 FMR3.092 (1.245–7.678)0.0152.829 (1.202–6.661)0.017
Multivariate analysis
 Age(< 65 years/≥ 65 years)7.446 (2.273–24.395)0.0012.592 (1.081–6.213)0.033
 Clinical stage (IIb/III)3.790 (1.104–13.013)0.034NA0.245
 Response (OR/non-OR)NA0.867NA0.427
 FMR2.914 (1.138–7.462)0.0263.009 (1.252–7.227)0.014
  1. OR objective response, BF blood flow, BV blood volume, TTP time to peak, SUVmax maximum standardized uptake value, MTV metabolic tumor volume, TLG total lesion glycolysis, FMR flow-metabolism ratio, HR hazard ratio, 95% CI 95% confidence interval