Table 4 68Ga-PSMA and 18F-DCFPyL uptake in tumor and contralateral brain in micro-PET for U87, 9 L, and F98 models (each group n = 5) quantified by SUV and TBR (mean ± SD). SUV in the brain was significantly higher for 68Ga-PSMA than for 18F-DCFPyL in all tumor models leading to higher TBR for 18F-DCFPyL in all tumor models. The differences have to be interpreted carefully, since the data are influenced by the different spatial resolution when using 68Ga or 18F
Model | Parameter | Region | [68Ga]PSMA | [18F] DCFPyL | p value |
|---|---|---|---|---|---|
U87 | SUV | Tumor | 0.31 ± 0.05 | 0.32 ± 0.07 | n.s. |
Brain | 0.10 ± 0.02 | 0.05 ± 0.01 | < 0.001 | ||
TBR |  | 3.26 ± 0.55 | 6.28 ± 0.68 | < 0.001 | |
9 L | SUV | Tumor | 0.46 ± 0.09 | 0.56 ± 0.11 | n.s. |
Brain | 0.12 ± 0.01 | 0.07 ± 0.02 | < 0.001 | ||
TBR |  | 3.92 ± 0.57 | 7.92 ± 1.99 | < 0.001 | |
F98 | SUV | Tumor | 0.39 ± 0.05 | 0.44 ± 0.04 | n.s. |
Brain | 0.12 ± 0.02 | 0.07 ± 0.01 | < 0.001 | ||
TBR |  | 3.22 ± 0.50 | 6.85 ± 1.33 | < 0.001 |