Table 3 Tracer uptake in autoradiography for all glioma models quantified by SUV (mean ± SD) and tumor-to-brain ratios (TBR, mean ± SD). SUV in the center of the tumors was significantly higher for 68Ga-PSMA than for 18F-DCFPyL in all tumor models. Furthermore, the TBR of tracer uptake at the tumor rim was significantly higher for 18F-DCFPyL than for 68Ga-PSMA in all tumor models. The differences have to be interpreted carefully, since the data may be influenced by the different spatial resolution when using 68Ga or 18F
Model | Parameter | Region | 68Ga-PSMA | 18F-DCFPyL | p value |
|---|---|---|---|---|---|
U87 | SUV | Tumor center | 0.39 ± 0.09 | 0.22 ± 0.08 | 0.005 |
Tumor rim | 0.77 ± 0.13 | 0.87 ± 0.13 | n.s. | ||
Brain | 0.016 ± 0.004 | 0.004 ± 0.002 | n.s. | ||
TBR | Tumor center | 25.1 ± 2.1 | 58.4 ± 13.1 | n.s. | |
Tumor rim | 50.0 ± 13.1 | 256.2 ± 27.9 | < 0.001 | ||
9 L | SUV | Tumor center | 0.85 ± 0.08 | 0.37 ± 0.20 | < 0.001 |
Tumor rim | 1.31 ± 0.28 | 0.85 ± 0.23 | < 0.001 | ||
Brain | 0.013 ± 0.001 | 0.006 ± 0.004 | n.s. | ||
TBR | Tumor center | 64.43 ± 6.65 | 69.86 ± 19.86 | n.s. | |
Tumor rim | 99.91 ± 23.17 | 181.17 ± 81.14 | 0.011 | ||
F98 | SUV | Tumor center | 0.43 ± 0.07 | 0.28 ± 0.02 | 0.006 |
Tumor rim | 0.78 ± 0.16 | 0.78 ± 0.09 | n.s. | ||
Brain | 0.013 ± 0.001 | 0.006 ± 0.002 | n.s. | ||
TBR | Tumor center | 34.10 ± 7.04 | 50.48 ± 20.79 | n.s. | |
Tumor rim | 62.39 ± 16.57 | 139.84 ± 48.27 | 0.001 |