Skip to main content

Table 2 Biokinetic modelling parameters for delineated regions

From: Human biodistribution and internal dosimetry of 4-[ 18F]fluorobenzyl-dexetimide: a PET radiopharmaceutical for imaging muscarinic acetylcholine receptors in the brain and heart

Region

Activity uptake model a

Fit parameters b

Cumulative activity

  

C0 (%)

C1 (%)

α (min−1)

β (min−1)

(MBq h/MBq)

Spleen

1

2.517

0.179

0.02624

0.00017

0.02659

Lungs

1

16.064

5.376

0.06423

0.00772

0.16487

Thyroid

1

0.239

0.109

0.09056

0.00909

0.00266

Kidneys

1

1.660

1.400

0.08843

0.00839

0.03360

Heart contents

1

2.470

0.763

0.02277

0.00377

0.04591

Stomach contents

1

0.881

0.0

0.01292

0.0

0.01354

Large intestine

1

0.665

0.0

0.00879

0.0

0.01408

Small intestine

1

1.084

0.0

0.00702

0.0

0.02680

Muscle tissue

1

26.771

0.0

0.00692

0.0

0.65455

Remaining tissue

1

23.314

0.0

0.00708

0.0

0.56611

Blood clearance cd

1

58.62

41.39

0.07824

0.00690

N/A

Myocardium (LV) d

2

0.201

0.630

0.13425

0.02971

0.00872

Red marrow

2

0.983

2.439

0.05047

0.00532

0.09511

Brain

2

2.485

4.072

0.09423

0.00715

0.16301

Liver

2

26.814

8.176

0.01704

0.01360

0.42313

Bladder model

 

A0,full (%)

λfill (min−1)

void time 1

void time 2

 
    

(min)

(min)

 

Bladder

3

6.3034

0.02329

34.92

162.36

0.10400

  1. aNumbering refers to the equation number in the text
  2. bThe parameters specified are applicable over the domain of 0≤t≤190 min
  3. cBlood clearance refers to a peak normalised percentage activity concentration in the blood
  4. dLeft ventricular (LV) myocardium and blood were incorporated into heart contents and remainder tissue in the dosimetric analysis