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EJNMMI Research

Table 1 Univariate analysis of the relationship between PD-L1 expression and PET/CT metabolic parameters, and clinicopathological characteristics

From: PD-L1 expression correlation with metabolic parameters of FDG PET/CT and clinicopathological characteristics in non-small cell lung cancer

 

Overall (n = 374)

 

Adenocarcinoma (n = 283)

 

Squamous cell carcinoma (n = 91)

 

Variable

PD-L1 positivity

(n = 104)

PD-L1 negativity

(n = 270)

P Value

PD-L1 positivity

(n = 61)

PD-L1 negativity

(n = 222)

P Value

PD-L1 positivity

(n = 43)

PD-L1 negativity

(n = 48)

P Value

Sex,n

 Male

72

143

0.004*

30

96

0.409

42

47

>0.999

 Female

32

127

 

31

126

 

1

1

 

Age (mean ± SD, range, years)

62 ± 9 (36–87)

63 ± 8 (32–83)

0.317

60 ± 10 (36–87)

63 ± 9 (32–86)

0.056

65 ± 7 (46–80)

66 ± 8 (43–83)

0.684

Smoking history,n

 Yes

71

134

0.001*

30

90

0.227

41

44

0.680

 No

33

136

 

31

132

 

2

4

 

Location,n

 Central

9

5

0.004*

0

0

/

9

5

0.245

 Peripheral

95

265

 

61

222

 

34

43

 

Diameter (mean ± SD, range, mm)

33 ± 15 (7-80)

32 ± 16 (8-110)

0.303

30 ± 12 (15-70)

29 ± 12 (8-120)

0.344

38 ± 18 (7-80)

45 ± 23 (11-110)

0.090

Cyfra211,n

 High level

27

46

0.051

5

24

0.545

22

22

0.659

 Normal level

73

213

 

54

190

 

19

23

 

TNM stage,n

 I

57

178

0.139

35

159

0.136

22

19

0.314

 II

28

49

 

11

31

 

17

18

 

 III

19

41

 

15

31

 

4

10

 

 IV

0

2

 

0

1

 

0

1

 

PET-CT parameters(mean ± SD,range)

 SUVmax

12.4 ± 6.0 (1.4-24.5)

8.3 ± 4.9 (1.1-20.8)

0.000*

10.0 ± 5.0 (1.4-23.2)

7.3 ± 4.5 (1.1-20.7)

0.000*

16.0 ± 5.6 (3.9-24.5)

13.2 ± 3.7 (4.9-20.8)

0.036*

 MTV-P

14.7 ± 18.3 (0.8-86.0)

12.7 ± 19.5 (0.7-168.9)

0.425

8.2 ± 6.8 (0.8-34.6)

9.6 ± 13.2 (0.7-139.8)

0.362

23.9 ± 24.7 (0.8-86.0)

27.4 ± 33.5 (0.8-168.9)

0.581

 TLG-P

143.0 ± 234.2 (1.9-1055.6)

78.9 ± 170.2 (1.5-1457.1)

0.008*

58.3 ± 81.4 (1.9-547.7)

46.7 ± 92.5 (1.5-947.0)

0.512

263.0 ± 316.0 (4.0-1055.6)

233.4 ± 316.1 (3.0-1457.1)

0.722

 MTV-C

15.8 ± 19.1 (0.8-86.0)

13.4 ± 19.7 (0.7-168.9)

0.322

9.2 ± 7.2 (1.0-34.6)

10.2 ± 13.4 (0.7-142.4)

0.523

25.2 ± 25.9 (0.8-86.0)

28.7 ± 33.4 (0.8-168.9)

0.603

 TLG-C

147.3 ± 237.2 (3.0-1112.9)

80.7 ± 171.1 (1.5-1457.1)

0.006*

62.2 ± 83.5 (3.0-547.7)

48.3 ± 93.4 (1.5-958.3)

0.423

268.1 ± 320.3 (4.0-1112.9)

236.2 ± 317.2 (3.0-1457.1)

0.698

EGFR mutation,n

Positive

32

113

0.059

29

113

0.787

3

0

0.104

Negative

64

141

 

27

97

 

37

44

 
  1. *P Value <0.05
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