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Table 1 Univariate analysis of the relationship between PD-L1 expression and PET/CT metabolic parameters, and clinicopathological characteristics

From: PD-L1 expression correlation with metabolic parameters of FDG PET/CT and clinicopathological characteristics in non-small cell lung cancer

  Overall (n = 374)   Adenocarcinoma (n = 283)   Squamous cell carcinoma (n = 91)  
Variable PD-L1 positivity
(n = 104)
PD-L1 negativity
(n = 270)
P Value PD-L1 positivity
(n = 61)
PD-L1 negativity
(n = 222)
P Value PD-L1 positivity
(n = 43)
PD-L1 negativity
(n = 48)
P Value
Sex,n
 Male 72 143 0.004* 30 96 0.409 42 47 >0.999
 Female 32 127   31 126   1 1  
Age (mean ± SD, range, years) 62 ± 9 (36–87) 63 ± 8 (32–83) 0.317 60 ± 10 (36–87) 63 ± 9 (32–86) 0.056 65 ± 7 (46–80) 66 ± 8 (43–83) 0.684
Smoking history,n
 Yes 71 134 0.001* 30 90 0.227 41 44 0.680
 No 33 136   31 132   2 4  
Location,n
 Central 9 5 0.004* 0 0 / 9 5 0.245
 Peripheral 95 265   61 222   34 43  
Diameter (mean ± SD, range, mm) 33 ± 15 (7-80) 32 ± 16 (8-110) 0.303 30 ± 12 (15-70) 29 ± 12 (8-120) 0.344 38 ± 18 (7-80) 45 ± 23 (11-110) 0.090
Cyfra211,n
 High level 27 46 0.051 5 24 0.545 22 22 0.659
 Normal level 73 213   54 190   19 23  
TNM stage,n
 I 57 178 0.139 35 159 0.136 22 19 0.314
 II 28 49   11 31   17 18  
 III 19 41   15 31   4 10  
 IV 0 2   0 1   0 1  
PET-CT parameters(mean ± SD,range)
 SUVmax 12.4 ± 6.0 (1.4-24.5) 8.3 ± 4.9 (1.1-20.8) 0.000* 10.0 ± 5.0 (1.4-23.2) 7.3 ± 4.5 (1.1-20.7) 0.000* 16.0 ± 5.6 (3.9-24.5) 13.2 ± 3.7 (4.9-20.8) 0.036*
 MTV-P 14.7 ± 18.3 (0.8-86.0) 12.7 ± 19.5 (0.7-168.9) 0.425 8.2 ± 6.8 (0.8-34.6) 9.6 ± 13.2 (0.7-139.8) 0.362 23.9 ± 24.7 (0.8-86.0) 27.4 ± 33.5 (0.8-168.9) 0.581
 TLG-P 143.0 ± 234.2 (1.9-1055.6) 78.9 ± 170.2 (1.5-1457.1) 0.008* 58.3 ± 81.4 (1.9-547.7) 46.7 ± 92.5 (1.5-947.0) 0.512 263.0 ± 316.0 (4.0-1055.6) 233.4 ± 316.1 (3.0-1457.1) 0.722
 MTV-C 15.8 ± 19.1 (0.8-86.0) 13.4 ± 19.7 (0.7-168.9) 0.322 9.2 ± 7.2 (1.0-34.6) 10.2 ± 13.4 (0.7-142.4) 0.523 25.2 ± 25.9 (0.8-86.0) 28.7 ± 33.4 (0.8-168.9) 0.603
 TLG-C 147.3 ± 237.2 (3.0-1112.9) 80.7 ± 171.1 (1.5-1457.1) 0.006* 62.2 ± 83.5 (3.0-547.7) 48.3 ± 93.4 (1.5-958.3) 0.423 268.1 ± 320.3 (4.0-1112.9) 236.2 ± 317.2 (3.0-1457.1) 0.698
EGFR mutation,n
Positive 32 113 0.059 29 113 0.787 3 0 0.104
Negative 64 141   27 97   37 44  
  1. *P Value <0.05