Fig. 5

Measurement of tissue oxygen saturation level in DU-145 xenografted mice treated with either DOTA-Miltuximab®, 3 MBq [¹⁷⁷Lu]Lu-DOTA-Miltuximab® or 6 MBq [¹⁷⁷Lu]Lu-DOTA-Miltuximab®. Photoacoustic imaging for oxygen saturation of haemoglobin in kidney and liver was performed on days 30 to 35 post Lu injection. a Representative images showing oxygen saturation levels in kidney and liver. b Quantitation of oxygen saturation in kidney and liver. Data are expressed as % oxygen saturation level, means are indicated by horizontal lines, and statistical analysis was performed using Dunnett’s multiple comparisons test. *p < 0.05