Fig. 1

[¹⁸F]-FDG PET scanning in control and D2 mutant animals under basal conditions or after the induction of a hyperdopaminergic state. Subtractive analysis of [¹⁸F]-FDG incorporation in the following: a control and mutant animals in basal conditions. b Control animals in basal condition and control animals in amphetamine-treated condition. c Mutant animals in basal condition and amphetamine-treated condition. d Control and mutant animals in amphetamine-treated conditions. [¹⁸F]-FDG incorporation is depicted in red-yellow color for metabolic activity increase in control animals (a), animals in basal conditions (b, c), or control animal after amphetamine treatment (d) or blue-white color for metabolic activity increase in mutant animals in basal condition (a) or animals after amphetamine treatment (b–d). t values for p < 0.05 are specified for each comparison. FrA frontal association cortex, M1/2 primary/secondary motor cortex, Or orbital cortex, PrL prelimbic cortex, InL infralimbic cortex, Cg cingulate cortex, Som somatosensory cortex, Ins insular cortex, Pir piriform cortex, Aud auditory cortex, Hipp hippocampus, Amyg amygdala, Re reuniens nucleus, Lat Hyp lateral hypothalamus