From: Toxicity of a combined therapy using the mTOR-inhibitor everolimus and PRRT with [177Lu]Lu-DOTA-TATE in Lewis rats
BUN (mg/dl)
Baseline
Week 16
Difference (%)
Placebo
16.9 ± 2.1
19.4 ± 1.8
19 ± 27
Everolimus
15.7 ± 2.0
18.3 ± 1.2
15 ± 11
Placebo + [177Lu]Lu-DOTA-TATE
17.9 ± 1.7
19.1 ± 2.2
7 ± 10
Everolimus + [177Lu]Lu-DOTA-TATE
16.9 ± 1.3
19.9 ± 1.1
19 ± 12