Fig. 2
SPM comparison of AD and CTL groups for PET- (a) and ASL-CBF (b), and RS-fMRI (c). All subject data of 27 AD and 16 CTL were applied in PET-CBF analysis, but only 25 AD datasets could be used for ASL-CBF comparison because of poor image quality due to artifacts. SPM analysis showed similar results of CBF reduction in AD group for both PET- and ASL-CBF comparison. Note the difference in the posterior cingulate cortex was observed only in the ASL-CBF analysis. RS-fMRI analysis showed significant decreases in the AD group in the anterior cingulate cortex and in the inferior part of the left precuneus (P < 0.005, cluster-level Puncorr < 0.05). No significant increases were observed in AD for all parameters