Fig. 1

Representative CBF (left) and SUVr (right) images of healthy control (CTL) (a), MCI (b), and early AD (c) calculated from [¹¹C]PiB-PET. MMSE scores were 30, 29, 25, respectively. SUVr images showed a gradual increase of cortical [¹¹C]PiB accumulation according to severity of the disease, but CBF values were close between controls and MCI patients. CBF (mL/min/100 g) images showed similar distribution between MCI and CTL, while early AD patients showed slight decrease in frontal and temporal lobes. Note the posterior cingulate cortex and the precuneus did not show CBF decrease and gradual SUVr increase in the AD patient