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Table 2 Diagnostic accuracy of 68Ga-PSMA PET/CT among 105 patients with a final diagnosis (BVC) for the presence or absence of bone metastases

From: Added value of 68Ga-PSMA PET/CT for the detection of bone metastases in patients with newly diagnosed prostate cancer and a previous 99mTc bone scintigraphy

 M0 by BVC,
n = 88
M1 by BVC,
n = 17
M0EquivocalM1M0EquivocalM1Sensitivity
(95% CI)
Specificity
(95% CI)
PPV
(95% CI)
NPV
(95% CI)
Three-point scale by three observers82240017
Optimistic analysis: Equivocal result considered M084 40 171.00 (0.81–1.00)0.96 (0.89–0.99)0.81 (0.58–0.95)1.00 (0.96–1.00)
Pessimistic analysis: equivocal result considered M182 60 171.00 (0.81–1.00)0.93 (0.86–0.98)0.74 (0.52–0.90)1.00 (0.96–1.00)
  1. BVC best valuable comparator, CI confidence interval, M0 no bone metastases, Equivocal findings are equivocal for bone metastases, M1 bone metastases present, PPV positive predictive value, NPV negative predictive value