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Table 2 Diagnostic accuracy of 68Ga-PSMA PET/CT among 105 patients with a final diagnosis (BVC) for the presence or absence of bone metastases

From: Added value of 68Ga-PSMA PET/CT for the detection of bone metastases in patients with newly diagnosed prostate cancer and a previous 99mTc bone scintigraphy

 

M0 by BVC,

n = 88

M1 by BVC,

n = 17

M0

Equivocal

M1

M0

Equivocal

M1

Sensitivity

(95% CI)

Specificity

(95% CI)

PPV

(95% CI)

NPV

(95% CI)

Three-point scale by three observers

82

2

4

0

0

17

Optimistic analysis: Equivocal result considered M0

84

 

4

0

 

17

1.00 (0.81–1.00)

0.96 (0.89–0.99)

0.81 (0.58–0.95)

1.00 (0.96–1.00)

Pessimistic analysis: equivocal result considered M1

82

 

6

0

 

17

1.00 (0.81–1.00)

0.93 (0.86–0.98)

0.74 (0.52–0.90)

1.00 (0.96–1.00)

  1. BVC best valuable comparator, CI confidence interval, M0 no bone metastases, Equivocal findings are equivocal for bone metastases, M1 bone metastases present, PPV positive predictive value, NPV negative predictive value