Coexistence of cerebral hypometabolism and neuroinflammation in the thalamo-limbic-brainstem region in young women with functional somatic syndrome

EJNMMI Research

Table 3 Correlation between [¹⁸F]FDG SUVR or [¹¹C]DPA713 BP_ND values and clinical scores

Clinical score	Anatomical region	Side	Correlation coefficient (r)	p value
a: [¹⁸F]FDG SUVR
WAIS-III
Working memory	Hippocampus	R	0.65	0.022
	Thalamus	R	0.64	0.025
	Thalamus	L	0.81	0.002*
Processing speed	Hippocampus	R	0.64	0.026
	Hippocampus	L	0.80	0.002*
	Amygdala	R	0.61	0.034
	Thalamus	R	0.84	< 0.001*
	Thalamus	L	0.67	0.017
WMS-R
Attention memory	Hippocampus	R	0.70	0.024
b: [¹¹C]DPA713 BP_ND
WAIS-III
Verbal comprehension	Hippocampus	L	− 0.77	0.003*
	Amygdala	L	− 0.62	0.031
	Anterior cingulate	R	− 0.71	0.009
	Anterior cingulate	L	− 0.74	0.006
	Thalamus	R	− 0.79	0.002*
	Thalamus	L	− 0.75	0.005
	Pons		− 0.81	0.001*
	Midbrain		− 0.58	0.049
WMS-R
Verbal memory	Hippocampus	L	− 0.67	0.024
	Amygdala	L	− 0.70	0.017
	Anterior cingulate	L	− 0.66	0.027
	Thalamus	R	− 0.85	< 0.001*
	Thalamus	L	− 0.69	0.018
	Pons		− 0.73	0.010

SUVR standardized uptake value ratio, BP_ND binding potential, L left, R right, WAIS-III Wechsler Adult Intelligence Scale-Third Edition, WMS-R Wechsler Memory Scale-Revised
*p < 0.05 with Bonferroni’s correction