Coexistence of cerebral hypometabolism and neuroinflammation in the thalamo-limbic-brainstem region in young women with functional somatic syndrome

Matsudaira, Takashi; Terada, Tatsuhiro; Obi, Tomokazu; Yokokura, Masamichi; Takahashi, Yukitoshi; Ouchi, Yasuomi

doi:10.1186/s13550-020-00617-1

EJNMMI Research

Table 2 Statistical parametric mapping results for [¹⁸F]FDG SUVR and [¹¹C]DPA-713 BP_ND

From: Coexistence of cerebral hypometabolism and neuroinflammation in the thalamo-limbic-brainstem region in young women with functional somatic syndrome

Anatomical region	BA	Talairach coordinate			Cluster size	Voxel T size	Z score	Cluster p value
Anatomical region	BA	x	y	z	Cluster size	Voxel T size	Z score	FWE	FDR	Uncorrected
a: [¹⁸F]FDG SUVR (FSS group vs. [¹⁸F]FDG PET control group)
R uncus	36	31.7	− 1.4	− 28.5	257	8.01	5.43	< 0.001	< 0.001	< 0.001
R hippocampus		31.7	− 8.7	− 19.7		7.28	5.14
R parahippocampus	34	17.8	− 0.8	− 15.1		6.76	4.92
L thalamus		− 9.9	− 29.3	− 3.6	356	6.70	4.90	< 0.001	< 0.001	< 0.001
L hippocampus		− 33.7	− 31.4	− 6.8	197	6.93	5.0	< 0.001	< 0.001	< 0.001
L insula	13	− 41.6	− 31.9	21.9	7	6.80	4.94	0.019	0.473	0.368
L anterior cingulate	25	0	− 0.34	− 6.7	141	6.75	4.92	< 0.001	0.001	0.001
L uncus	28	− 21.8	2.5	− 27.0	3	6.16	4.65	0.029	0.566	0.566
b: [¹¹C]DPA-713 BP_ND (FSS group vs. [¹¹C]DPA713 PET control group)
L thalamus		− 4.0	− 27.2	− 2.0	4560	10.18	6.41	< 0.001	< 0.001	< 0.001
L amygdala		− 25.7	− 1.2	− 23.5	208	7.78	5.54	< 0.001	< 0.001	< 0.001
L hippocampus		− 25.7	− 14.2	− 11.1		7.30	5.34
L parahippocampus	34	− 17.8	− 6.7	− 18.2		5.72	5.07
R inferior temporal gyrus	20	55.4	− 13.1	− 29.6	58	7.35	5.36	< 0.001	0.034	0.009
R middle temporal gyrus	20	55.4	− 39.6	− 29.6	61	7.22	5.30	< 0.001	0.034	0.008
R fusiform gyrus	20	55.4	− 34.0	− 20.2		6.90	5.15
R middle temporal gyrus	21	49.5	4.55	− 25.5	144	7.11	5.25	< 0.001	0.001	< 0.001
L superior temporal gyrus	38	− 37.6	12.2	− 27.5	31	6.79	5.10	0.002	0.12	0.047
L fusiform gyrus	20	− 55.4	− 16.6	− 21.0	22	6.71	5.07	0.004	0.182	0.087
L superior frontal gyrus	6	− 5.9	8.9	62.2	20	6.49	4.96	0.005	0.182	0.101
L middle frontal gyrus	11	− 27.7	34.4	− 11.8	21	6.46	4.95	0.005	0.182	0.094
R insula	30	41.6	− 26.2	19.7	12	6.16	4.80	0.010	0.321	0.196

SUVR standardized uptake value ratio, BP_ND binding potential, BA Brodmann’s area, L left, R right, FWE family-wise error, FDR false discovery rate

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