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Fig. 7 | EJNMMI Research

Fig. 7

From: [18F]ML-10 PET imaging fails to assess early response to neoadjuvant chemotherapy in a preclinical model of triple negative breast cancer

Fig. 7

In vivo imaging analysis of baseline PET imaging. a SUVmean showing uptake of [18F]ML-10 in MDA-MB-231 subcutaneous xenograft tumor, MDA-MB-468 subcutaneous xenograft tumor, and MDA-MB-468 orthotopic xenograft tumor and muscle. The Mann-Whitney test was performed (***p < 0.001). b Flow cytometric quantitation of cell apoptosis was compared with cell-associated radioactivity for [18F]ML-10. Pearson correlation was performed (***p < 0.001). c SUVmean showing uptake of [18F]FDG, [18F]FMISO, and [18F]ML-10 in MDA-MB-468 subcutaneous or orthotopic xenograft tumor. The Mann-Whitney test was performed (*p < 0.05, **p < 0.01, ***p < 0.001). Correlation SUVmean of [18F]FDG d or [18F]FMISO e uptake in tumor with SUVmean of [18F]ML-10. Pearson correlation was performed (*p < 0.05)

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