Fig. 10
Evaluation of early response by [18F]ML-10 PET imaging on an orthotopic model. a Evaluation of tumor volume after two i.v. injections of paclitaxel (20 mg/kg) at a 72-h interval. Data are represented as mean ± SD. Compared to control, ***p < 0.001 (Mann-Whitney test). b Images of [18F]ML-10 PET of representative MDA-MB-468 orthotopic xenograft model performed and 72-h post-treatment. T represented tumor. c Representative image of cleaved caspase of tumor tissues. d [18F]ML-10 uptake expressed as SUVmean in tumor control, tumor treated and muscle at day 0, day 3, and day 6. Mann-Whitney test was performed (*p < 0.05)