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Fig. 1 | EJNMMI Research

Fig. 1

From: 64Cu-ATSM/64Cu-Cl2 and their relationship to hypoxia in glioblastoma: a preclinical study

Fig. 1

In vivo uptake of 64Cu-ATSM and 64Cu-Cl2 in C6 glioblastoma model. a MRI and PET images were acquired 15 days after tumor cell implantation into the striatum. 64Cu-ATSM and 64Cu-Cl2 uptake were evaluated at early (3 h) and late (24 h) times after radiotracer injection. Quantification of 64Cu-ATSM and 64Cu-Cl2 uptake from ipsilateral (tumor) and contralateral (healthy brain) SUVs (b) or ratio between tumor and contralateral SUVs (c) at the different imaging points. Mean ± SD, n = 6 rats for 64Cu-ATSM and n = 11 rats for 64Cu-Cl2. Tukey’s HSD test after significant two-ways ANOVA (group and time factors): *p < 0.05, **p < 0.01, and ***p < 0.001

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