Fig. 1

Demyelination and remyelination in five representative lesions on pre- and post-treatment ¹⁸F-florbetapir PET/MRI. a–f Pre-treatment PET/MRI showed multifocal hyperintense lesions (white arrow) with decreased ¹⁸F-florbetapir uptake (SUVR = 0.75, 0.75, 0.78, 0.67, and 0.77). g–l Five months later, reduced hyperintense lesions with increased ¹⁸F-florbetapir uptake (SUVR = 0.85, 0.82, 0.80, 0.80 and 0.86) were observed on post-treatment PET/MRI