Fig. 1

Workflow of the study. (i) Intra-individual registration of post-treatment data to the pre-treatment space allows the definition of both the region of recurrence volume (GTVfailure) and the responder volume (GTVresponder). This step is followed by (ii) a regional analysis allowing to characterize the recurrence and (iii) a voxel-wise analysis (feature extraction and classification) which yields a probability map of recurrence