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Table 3 Biodistribution of [125I]CPCR4.3 in Black Six normal mice at 60 min p.i. (groups of n = 4). To determine CXCR4 specificity of tracer uptake, 50 μg AMD3100 (2 mg/kg) were coinjected. Data are cited as %iD/g and are means ± SD

From: Validation of [125I]CPCR4.3 as an investigative tool for the sensitive and specific detection of hCXCR4 and mCXCR4 expression in vitro and in vivo

Organ Tracer only Coinjection of AMD3100
Blood 0.39 ± 0.05 0.32 ± 0.11
Heart 0.36 ± 0.10 0.34 ± 0.10
Liver 21.18 ± 2.92 23.74 ± 4.68
Stomach 4.63 ± 2.94 1.08 ± 0.59
Pancreas 1.14 ± 0.87 0.42 ± 0.21
Intestine 30.36 ± 2.09 35.67 ± 2.48
Kidney 4.07 ± 0.25 4.70 ± 1.11
Lung 1.65 ± 0.25 0.49 ± 0.07*
Spleen 8.03 ± 2.91 2.78 ± 1.72*
Adrenals 1.43 ± 0.37 0.33 ± 0.14*
Muscle 0.13 ± 0.11 0.07 ± 0.05
  1. *p < 0.005